3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)Pyridin-3-Yl]Phenol 3-[6-氨基-5-(3,4,5-三甲氧苯基)吡啶-3-基]苯酚

CAS 1431985-92-0 MFCD531985920

化学结构图

1431985-92-0
SMILES: COc1cc(-c2cc(-c3cccc(O)c3)cnc2N)cc(OC)c1OC

化学属性

Mol. Weight352
Appearance Solid powder
SolubilitySoluble in DMSO, not in water
Mol. FormulaC20H20N2O4

别名和识别编码

Chemical Name Translation3-[6-氨基-5-(3,4,5-三甲氧苯基)吡啶-3-基]苯酚
Chemical Name3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)Pyridin-3-Yl]Phenol
FormulaC20H20N2O4
Synonym K-02288; K 02288; K 02288.
IUPAC Name3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol
InChIKeyCJLMANFTWLNAKC-UHFFFAOYSA-N
InChIInChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
Canonical SMILESOC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
MDL Number
CAS Number1431985-92-0
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产品应用

  • K02288 is a potent inhibitor of BMP signaling. K02288 has in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Stem Cells / Wnt
  3. TGF-beta/Smad

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