1-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid 1-((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)-4-(2-羟丙基-2-基)-2-丙基-1H-咪唑-5-羧酸

CAS 144689-24-7 MFCD44689247

化学结构图

144689-24-7
SMILES: CCCC1=NC(=C(C(O)=O)N1CC1C=CC(=CC=1)C1C=CC=CC=1C1=NNN=N1)C(C)(C)O

化学属性

Mol. Weight446.5
Mol. FormulaC24H26N6O3

别名和识别编码

CAS Number144689-24-7
Chemical Name1-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid
Synonym 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2?-(1H-tetazol-5-yl)[1,1?-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid CS 088 RNH 6270
Chemical Name Translation1-((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)-4-(2-羟丙基-2-基)-2-丙基-1H-咪唑-5-羧酸
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分类

  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • An angiotensin II receptor antagonist. Used as an anti-hypertensive.

相关文献及参考

  • [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.
  • [3]. Bakhtiari E, et al. Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line. Toxicol Mech Methods. 2015;25(8):614-21.
  • Puchler, K., et al.: J. Hypertens., 15, 1809 (1997),
  • Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),
  • [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
  • [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
  • [2].

安全信息

GHS Symbol

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Angiotensin Receptor  (血管紧张素受体)

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