(2S,3S)-2-Benzhydryl-N-(5-(Tert-Butyl)-2-Methoxybenzyl)Quinuclidin-3-Amine (2S,3S)-2-二苯甲基-N-(5-(叔丁基)-2-甲氧基苄基)奎宁环-3-胺

CAS 147116-67-4 MFCD47116674

化学结构图

147116-67-4
SMILES: CC(C)(C)C1=CC(CN[C@@H]2[C@H](C(C3C=CC=CC=3)C3C=CC=CC=3)N3CCC2CC3)=C(C=C1)OC |&1:9,10|

化学属性

Mol. Weight468.67
Mol. FormulaC32H40N2O

别名和识别编码

CAS Number147116-67-4
Chemical Name(2S,3S)-2-Benzhydryl-N-(5-(Tert-Butyl)-2-Methoxybenzyl)Quinuclidin-3-Amine
Synonym (2S-cis)-N-[[5-(1,1-Dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
Chemical Name Translation(2S,3S)-2-二苯甲基-N-(5-(叔丁基)-2-甲氧基苄基)奎宁环-3-胺
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Maropitant is a neurokinin type 1 (NK-1) receptor antagonist. Recent studies show that Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in

相关文献及参考

  • [2]. Lesman SP, Boucher JF, Grover GS, et al. The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kg once daily for 14 days consecutive days. J Vet Pharmacol Ther. 2012 Nov 20.
  • [3]. Alvillar BM, Boscan P, Mama KR, et al. Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs. Vet Anaesth Analg. 2012 Mar;39(2):201-5.
  • [4]. Ramsey DS, Kincaid K, Watkins JA et al. Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs. J Vet Pharmacol Ther. 2008 Dec;31(6):538-43. doi: 10.1111/j.1365-2885.2008.00992.x.
  • [5]. Benchaoui HA, Cox SR, Schneider RP et al. The pharmacokinetics of maropitant, a novel neurokinin type-1 receptor antagonist, in dogs. J Vet Pharmacol Ther. 2007 Aug;30(4):336-44.
  • [6]. Maropitant

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Neurokinin Receptor  (神经激肽受体)

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