4-羧基-1,3-氧氮杂戊 4-羧基-1,3-氧氮杂戊

CAS 153259-65-5 MFCD53259655

化学结构图

153259-65-5
SMILES: COc1ccc(C2(C#N)CCC(C(=O)O)CC2)cc1OC1CCCC1

化学属性

Mol. Weight343.42
Mol. FormulaC20H25NO4

别名和识别编码

CAS Number153259-65-5
Chemical Name4-羧基-1,3-氧氮杂戊
Synonym Ariflo Cilomilast SB 207499 cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic Acid
Chemical Name Translation4-羧基-1,3-氧氮杂戊
PubChem Substance ID151170
InChIInChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)
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分类

  • Aromatics
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Selective phosphodiesterase 4 (PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.

相关文献及参考

  • [2]. Hatzelmann A, et, al. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther. 2001 Apr;297(1):267-79.
  • [3]. Barnette MS, et, al. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
  • Barnette, M.S., et al.: J. Pharmacol. Exp. Ther., 284, 420 (1998),
  • Torphy, TJ., et al.: Pulm. Pharmacol. Ther., 12, 131 (1999),
  • Zussman, B.D., et al.: Pharmacotherapy, 21, 653 (2001),
  • [1]. Griswold DE, et, al. SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo. J
  • [1]. Griswold DE, et, al. SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Phosphodiesterase (PDE)  (磷酸二酯酶)

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