Alvimopan 爱维莫潘

CAS 156053-89-3 MFCD56053893

化学结构图

156053-89-3
SMILES: C[C@H]1CN(C[C@H](CC2C=CC=CC=2)C(=O)NCC(O)=O)CC[C@@]1(C)C1C=C(O)C=CC=1

化学属性

Mol. Weight425
Mol. FormulaC25H32N2O4

别名和识别编码

CAS Number156053-89-3
Chemical NameAlvimopan
Synonym N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine ADL 8-2698 LY 246736 Entereg
Chemical Name Translation爱维莫潘
MDL Number
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分类

  • Aromatics
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A peripheral ?-opioid receptor antagonist. Gastroprokinetic.

相关文献及参考

  • [2]. Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83.
  • [3]. Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53.
  • Liu, S.S., et al.: Clin. Pharmacol. Ther., 68, 66 (2000),
  • Taguchi, A., et al.: N. Engl. J. Med., 345, 935 (2001),
  • Zimmerman, D.M., et al.: J. Med. Chem., 37, 2262 (1994),
  • [1]. Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12.
  • [1]. Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12.
  • [2]. Erowele

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Opioid Receptor  (阿片受体)

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