Dehydro Olmesartan 1-((2'-(1H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-4-(丙-1-烯-2-基)-2-丙基-1H-咪唑-5-羧酸

CAS 172875-98-8 MFCD72875988

化学结构图

172875-98-8
SMILES: CC(=C)C1N=C(CCC)N(CC2C=CC(=CC=2)C2C=CC=CC=2C2=NNN=N2)C=1C(O)=O

化学属性

Mol. Weight428.49
Mol. FormulaC24H24N6O2

别名和识别编码

CAS Number172875-98-8
Chemical NameDehydro Olmesartan
Synonym 4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
Chemical Name Translation1-((2'-(1H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-4-(丙-1-烯-2-基)-2-丙基-1H-咪唑-5-羧酸
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分类

  • Aromatics
  • Heterocycles
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Olmesartan acid (O550001) derivative. A nonpeptide angiotensin II receptor antagonist.

相关文献及参考

  • [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.
  • Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),
  • [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
  • [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
  • [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Angiotensin Receptor  (血管紧张素受体)

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