Rupatadine Fumarate 富马酸卢帕他定

CAS 182349-12-8 MFCD82349128

化学结构图

182349-12-8
SMILES: CC1C=NC=C(CN2CCC(CC2)=C2C3N=CC=CC=3CCC3=CC(Cl)=CC=C32)C=1.OC(=O)/C=C/C(O)=O

化学属性

Mol. Weight532.03
Mol. FormulaC30H30ClN3O4

别名和识别编码

CAS Number182349-12-8
Chemical NameRupatadine Fumarate
Synonym 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2E)-2-Butenedioate Rupafin
Chemical Name Translation富马酸卢帕他定
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Rupatadine is a dual antagonist of histamine H1 and platelet-activating factor receptors. Rupatadine is used as an antihistaminic.

相关文献及参考

  • [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.
  • [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.
  • Guadano, E.M., et al.: Allergy, 59, 766 (2004),
  • Merlos, M., et al.: J. Pharmacol. Exp. Ther., 280, 114 (1997),
  • [1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.
  • [1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.
  • [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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