Eptifibatide 依菲巴特
CAS 188627-80-7 MFCD88627807
化学结构图
SMILES: NC(=O)[C@@H]1CSSCCC(=O)N[C@@H](CCCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC2=CNC3C=CC=CC2=3)C(=O)N2CCC[C@H]2C(=O)N1
化学属性
| Mol. Weight | 832 |
|---|---|
| Mol. Formula | C35 |
别名和识别编码
| CAS Number | 188627-80-7 |
|---|---|
| Chemical Name | Eptifibatide |
| Synonym | N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-.alpha.-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide Cyclic (16)-Disulfide Integrelin Integrilin Intrifiban |
| Chemical Name Translation | 依菲巴特 |
| MDL Number |
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分类
- Peptides
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A Arginin-glycin-aspartat-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.
相关文献及参考
- Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),
- Hantgan, R., et al.: Biochem., 48, 8355 (2009),
- Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008),
- [1]. Gilchrist IC, et al. Platelet glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention: focus on the pharmacokinetic-pharmacodynamic relationships of eptifibatide. Clin Pharmacokinet. 2003;42(8):703-20.
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