CAS 194423-06-8 MFCD94423068-CL-387785 N-(4-((3-溴苯基)氨基)喹唑啉-6-基)丁-2-炔酰胺 -LabNovo

SMILES: CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1

Chemical Name	CL-387785
Chemical Name Translation	N-(4-((3-溴苯基)氨基)喹唑啉-6-基)丁-2-炔酰胺
Chemicalbook ID	CB92626313
Formula	C18H13BrN4O
Synonym	CL387785; CL 387785; CL-387785; EKI785; EK-I785; EK I785.
IUPAC Name	N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
InChIKey	BTYYWOYVBXILOJ-UHFFFAOYSA-N
InChI	InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)
Canonical SMILES	CC#CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O

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CL-387785, also known as EKI-785 , is a n irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility.

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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