(E)-5-Chloro-2-(2-(Phenyl(Pyridin-2-Yl)Methylene)Hydrazinyl)Pyridine (E)-5-氯-2-(2-(苯基(吡啶-2-基)亚甲基)肼基)吡啶

CAS 199596-05-9 MFCD99596059

化学结构图

199596-05-9
SMILES:

化学属性

Mol. Weight308.76
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation(E)-5-氯-2-(2-(苯基(吡啶-2-基)亚甲基)肼基)吡啶
Chemical Name(E)-5-Chloro-2-(2-(Phenyl(Pyridin-2-Yl)Methylene)Hydrazinyl)Pyridine
FormulaC17H13ClN4
Synonym JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627.
IUPAC Name(E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
InChIKeyYHHFKWKMXWRVTJ-OQKWZONESA-N
InChIInChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
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产品应用

  • JIB-04, also known as NSC 693627, is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Epigenetics
  3. Histone Demethylase

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