LB42708

CAS 226929-39-1 MFCD26929391

化学结构图

226929-39-1
SMILES: O=C(c1cn(Cc2cncn2Cc2ccc(Br)cc2)cc1-c1cccc2ccccc12)N1CCOCC1

化学属性

Mol. Weight555.46
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation
Chemical NameLB42708
FormulaC30H27BrN4O2
Synonym LB42708; LB-42708; LB 42708.
IUPAC Name(1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
InChIKeyGUUIRIMAQGOLHT-UHFFFAOYSA-N
InChIInChI=1S/C30H27BrN4O2/c31-24-10-8-22(9-11-24)17-35-21-32-16-25(35)18-33-19-28(27-7-3-5-23-4-1-2-6-26(23)27)29(20-33)30(36)34-12-14-37-15-13-34/h1-11,16,19-21H,12-15,17-18H2
Canonical SMILESO=C(C1=CN(CC2=CN=CN2CC3=CC=C(Br)C=C3)C=C1C4=C5C=CC=CC5=CC=C4)N6CCOCC6
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产品应用

  • LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FAK
  1. Medical Research Areas
  2. Angiogenesis
  3. Src
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. FAK

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