Solifenacin SuccinateSolifenacin 索利那辛琥珀酸盐

CAS 242478-38-2 MFCD42478382

化学结构图

242478-38-2
SMILES: [2H]C1=C([C@H]2C3C=CC=CC=3CCN2C(=O)O[C@H]2CN3CCC2CC3)C([2H])=C([2H])C([2H])=C1[2H]

化学属性

Mol. Weight480.56
Mol. FormulaC23H26N2O2·C4H6O4
Melting Point145.0 to 149.0 deg-C

别名和识别编码

CAS Number242478-38-2
Chemical NameSolifenacin SuccinateSolifenacin
Synonym (1S)-(3R)-1-Azabicyclo[2.2.2]oct-3-yl 3,4-Dihydro-1-phenyl-2(1H)-
Chemical Name Translation索利那辛琥珀酸盐
LabNetwork Molecule IDLN01310086
MDL NumberMFCD09952287
PubChem Substance ID253662487
Merck Number8712
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分类

  • Amines
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence.

相关文献及参考

  • [2]. Ohtake A, Sato S, Sasamata M, Miyata K.The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgency episodes.J Pharmacol Sci. 2010;112(2):135-41. Epub 2010 Feb 4.
  • [3]. Hoffstetter S, Leong FC.Solifenacin succinate for the treatment of overactive bladder.Expert Opin Drug Metab Toxicol. 2009 Mar;5(3):345-50.
  • [4]. Choo MS, Lee JZ, Lee JB, Kim YH, Jung HC, Lee KS, Kim JC, Seo JT, Paick JS, Kim HJ, Na YG, Lee JG.Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.Int J Clin Pract. 2008 Nov;62(11):1675-83.
  • [5]. Imamura T, et al.Combined treatment with a β3 -adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSNW7136000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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