(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate) 福沙吡坦二甲葡胺

CAS 265121-04-8 MFCD65121048

化学结构图

265121-04-8
SMILES:

化学属性

Mol. Weight1,004.83
Mol. FormulaC37H56F7N6O16P

别名和识别编码

CAS Number265121-04-8
Chemical Name(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Synonym [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate 1-Deoxy-1-(methylamino)-D-glucitol MK 0517
Chemical Name Translation福沙吡坦二甲葡胺
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分类

  • Aromatics
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Phosphorylating and Phosphitylating Agents

产品应用

  • Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

相关文献及参考

  • Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001),
  • Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000),
  • [1]. Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48(4): 394-398.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Neurokinin Receptor  (神经激肽受体)

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