Avosentan

CAS 290815-26-8 MFCD90815268

化学结构图

290815-26-8
SMILES: CC1C=CC(=NC=1)S(=O)(=O)NC1=NC(=NC(OC)=C1OC1=CC=CC=C1OC)C1C=CN=CC=1

化学属性

Mol. Weight479.51
Mol. FormulaC23H21N5O5S

别名和识别编码

CAS Number290815-26-8
Chemical NameAvosentan
Synonym N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide Ro 67-0565 SPP 301
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分类

  • Aromatics
  • Heterocycles
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.

相关文献及参考

  • [2]. Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J.
  • [3]. Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group.
  • [4]. Dieterle W, Hengelage T.
  • [5]. Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos, Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.
  • Absolute bioavailability and pharmacokinetics of avosentan in man.
  • Absolute bioavailability and pharmacokinetics of avosentan in man.
  • Antidiuretic effects of the endothelin receptor antagonist avosentan.
  • Antidiuretic effects of the endothelin receptor antagonist avosentan.
  • Curr Eye Res. 2011 Feb;36(2):118-24.
  • Curr Eye Res. 2011 Feb;36(2):118-24.
  • Dieterle, W. et al.: J. Clin. Pharmacol., 44, 59 (2004); Dieterle, W. et al.: Int. J. Clin. Pharmacol. Ther., 43, 178 (2005); Wan

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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