3,5-Dichloro-4-(3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzamido)Pyridine 1-Oxide 3,5-二氯-4-[3-(环丙基甲氧基)-4-(二氟甲氧基)苯甲酰胺]吡啶1-氧化物
CAS 292135-78-5 MFCD92135785
化学结构图
SMILES: [O-][N+]1C=C(Cl)C(NC(=O)C2=CC(OCC3CC3)=C(C=C2)OC(F)F)=C(Cl)C=1
化学属性
| Mol. Weight | 419.21 |
|---|---|
| Mol. Formula | C17H14Cl2F2N2O4 |
别名和识别编码
| CAS Number | 292135-78-5 |
|---|---|
| Chemical Name | 3,5-Dichloro-4-(3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzamido)Pyridine 1-Oxide |
| Synonym | 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-4-(difluoromethoxy)benzamide N-(3,5-Dichloro-1-oxopyridin-4-yl)-4-difluoromethoxy-3-cyclopropyl- |
| Chemical Name Translation | 3,5-二氯-4-[3-(环丙基甲氧基)-4-(二氟甲氧基)苯甲酰胺]吡啶1-氧化物 |
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分类
- Heterocycles
- Metabolites & Impurities
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Roflumilast-N-oxide is the active metabolite of Roflumilast (R639700).
相关文献及参考
- [2]. Milara J,et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015 Jun;12(3):320-31.
- [3]. Vollert S, et al. The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice. Diabetologia. 2012 Oct;55(10):2779-2788.
- Chiba, M., et al.: Drug Metab. Dispos., 25, 1022
- [1]. Victoni T, et al. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells. Int Immunopharmacol. 2016 Jan;30:1-8.
- [1]. Victoni T, et al. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells. Int Immunopharmacol. 2016 Jan;30:1-8.
- [2]. Milara J,et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induce
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