Mepazine hydrochloride 哌卡嗪盐酸盐

CAS 2975-36-2 MFCD02975362

化学结构图

2975-36-2
SMILES: CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1.Cl

化学属性

Mol. FormulaC19H22N2S.ClH
Mol. Weight346.95

别名和识别编码

Chemical NamePhenothiazine, 10-((1-methyl-3-piperidyl)methyl)-,monohydrochloride
Chemical Name Translation哌卡嗪盐酸盐
Chemicalbook IDCB3921722
Wiswesser Line NotationT C666 BN ISJ B1- CT6NTJ A1 &GH
Synonym Pecazine hydrochloride Mepazine chloride Pecazine monohydrochloride 10-((1-Methyl-3-piperidyl)methyl)phenothiazine hydrochloride Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-, hydrochloride Mepazine hydrochloride 1-Pipecoline, 3-(phenothiazin-10-yl)methyl-, hydrochloride
CAS Number2975-36-2
LabNetwork Molecule IDLN04620831
PubChem Substance ID102907
InChIInChI=1S/C19H22N2S.ClH/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21;/h2-5,8-11,15H,6-7,12-14H2,1H3;1H
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相关文献及参考

  • [1]. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.

安全信息

RTECSSP2800000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   19,87,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 6,365,1957

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,28,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,28,1972

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系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. MALT1  (黏膜相关淋巴瘤转运蛋白1)

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