(R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide (R)-5-(6-环己基-1-(羟基氨基)-1-氧代己-3-基)-1,2,4-恶二唑-3-甲酰胺
CAS 348622-88-8 MFCD48622888
化学结构图
SMILES:
化学属性
| Mol. Weight | 324.38 |
|---|---|
| Mol. Formula | C15H24N4O4 |
别名和识别编码
| CAS Number | 348622-88-8 |
|---|---|
| Chemical Name | (R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide |
| Synonym | (?R)-3-(Aminocarbonyl)-?-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide 5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide UK 383367 PF-0417142 |
| Chemical Name Translation | (R)-5-(6-环己基-1-(羟基氨基)-1-氧代己-3-基)-1,2,4-恶二唑-3-甲酰胺 |
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分类
- Heterocycles
- Inhibitors
- Pfizer Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Potent and selective nonpeptidic inhibitor of procollagen C-proteinase (PCP) inhibitor. A potential dermal anti-scarring agent.
相关文献及参考
- [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562.
- Fish, P.V. et al.: J. Med. Chem., 50, 3442 (2007); Allan, G.A. et al.: Xenobiotica, 36, 399 (2006); Bailey, S. et al.: Biorog. Med. Chem. Lett., 18, 6562 (2008);
- [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418.
- [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418.
- [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteina
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