CHF-4227

CAS 444643-64-5 MFCD44643645

化学结构图

444643-64-5
SMILES: COc1ccc(C2=C(Cc3ccc(OCCN4CCCCC4)cc3)c3ccc(O)cc3OC2)cc1

化学属性

Mol. Weight471.59
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameCHF-4227
FormulaC30H33NO4
Synonym CHF4227; CHF 4227; CHF-4227.
IUPAC Name3-(4-methoxyphenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)benzyl)-2H-chromen-7-ol
InChIKeyZUDXUNPSRMREOJ-UHFFFAOYSA-N
InChIInChI=1S/C30H33NO4/c1-33-25-12-7-23(8-13-25)29-21-35-30-20-24(32)9-14-27(30)28(29)19-22-5-10-26(11-6-22)34-18-17-31-15-3-2-4-16-31/h5-14,20,32H,2-4,15-19,21H2,1H3
Canonical SMILESOC1=CC=C2C(CC3=CC=C(OCCN4CCCCC4)C=C3)=C(C5=CC=C(OC)C=C5)COC2=C1
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产品应用

  • CHF-4227 is a novel potent and selective estrogen receptor modulator. CHF 4227 binds with high affinity to the human estrogen receptor-alpha and -beta (dissociation constant K(i) = 0.017 and 0.099 nM, respectively). CHF 4227 compares favorably in efficacy and potency with raloxifene in preventing bone loss and in antagonizing EE2 stimulation of the uterus. This profile along with the minimal uterine stimulation suggests a therapeutic advantage to CHF 4227 over EE2 or raloxifene for the treatment of postmenopausal women. CHF 4227 is a well-tolerated SERM when administered once daily for 28 days. It is potentially active on bone resorption and serum lipids, without affecting the endometrium and without worsening hot flushes. CHF 4227 is a promising agent for the treatment of several conditions in postmenopausal women.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Endocrinology & Hormones
  3. Estrogen/progestogen Receptor

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