CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).

CAS 467421-06-3 MFCD67421063

化学结构图

467421-06-3
SMILES: NC(=O)CC(c1ccccc1)N1C(=O)c2ccccc2C1=O

化学属性

Mol. Weight294.31
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameCC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).
FormulaC17H14N2O3
Synonym CC1088; CC 1088; CC-1088.
IUPAC Name3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide
InChIKeyZJZWDDCSXLSDJG-UHFFFAOYSA-N
InChIInChI=1S/C17H14N2O3/c18-15(20)10-14(11-6-2-1-3-7-11)19-16(21)12-8-4-5-9-13(12)17(19)22/h1-9,14H,10H2,(H2,18,20)
Canonical SMILESO=C(C1=CC=CC=C12)N(C(C3=CC=CC=C3)CC(N)=O)C2=O
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产品应用

  • CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. PDE

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