(S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (S)-4-((2-(3-氯苯基)-2-羟乙基)氨基)-3-(4-甲基-6-吗啉-1H-苯并[d]咪唑-2-基)吡啶-2(1H)-酮

CAS 468740-43-4 MFCD68740434

化学结构图

468740-43-4
SMILES: Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12

化学属性

Mol. FormulaC25H26ClN5O3
Mol. Weight479.96
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name(S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
Chemical Name Translation(S)-4-((2-(3-氯苯基)-2-羟乙基)氨基)-3-(4-甲基-6-吗啉-1H-苯并[d]咪唑-2-基)吡啶-2(1H)-酮
Chemicalbook IDCB22510062
FormulaC25H26ClN5O3
Synonym BMS536924; BMS-536924; BMS 536924.
IUPAC Name(S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
InChIKeyZWVZORIKUNOTCS-OAQYLSRUSA-N
InChIInChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1
Canonical SMILESO=C1C(C2=NC3=C(C)C=C(N4CCOCC4)C=C3N2)=C(NC[C@H](C5=CC=CC(Cl)=C5)O)C=CN1
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产品应用

  • BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. NF-kB
  3. Akt
  1. Medical Research Areas
  2. Protein Tyrosine Kinase
  3. IGF-1R

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