Genz-123346 free base

CAS 491833-30-8 MFCD91833308

化学结构图

491833-30-8
SMILES: CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2c(c1)OCCO2

化学属性

Mol. Weight418.57
Appearance White to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

PubChem Substance ID23652732
InChIInChI=1S/C24H38N2O4/c1-2-3-4-5-6-7-10-23(27)25-20(18-26-13-8-9-14-26)24(28)19-11-12-21-22(17-19)30-16-15-29-21/h11-12,17,20,24,28H,2-10,13-16,18H2,1H3,(H,25,27)/t20-,24-/m1/s1
Synonym (2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide Genz 123346 Genz-123346 Genz123346 Genz123346; Genz-123346; Genz 123346
Chemical Name Translation
Chemical NameGenz-123346
FormulaC24H38N2O4
IUPAC NameN-[(1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide
InChIKeyJMNXWOFCUJJYEO-HYBUGGRVSA-N
Canonical SMILESCCCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C3OCCOC3=C2)O)=O
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产品应用

  • Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Transmembrane Transporters
  3. P-gp
  1. Medical Research Areas
  2. Neuronal Signaling
  3. P-gp

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