1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine [1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺
CAS 670220-88-9 MFCD70220889
化学结构图
SMILES: CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1
化学属性
| Mol. Weight | 443.54 |
|---|---|
| Mol. Formula | C26H29N5O2 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 670220-88-9 |
|---|---|
| Chemical Name | 1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine |
| Synonym | 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine ARO 002 CP 868596 CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; Crenolanib. [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]ami |
| Chemical Name Translation | [1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺 |
| Formula | C26H29N5O2 |
| IUPAC Name | 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine. |
| InChIKey | DYNHJHQFHQTFTP-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3 |
| Canonical SMILES | NC1CCN(C2=C3N=C(N4C=NC5=CC(OCC6(C)COC6)=CC=C45)C=CC3=CC=C2)CC1 |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Tyrosine Kinase Inhibitors
产品应用
- Crenolanib is a n orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation.
相关文献及参考
- Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);
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