(Z)-3-((Z)-Benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione (Z)-3-((Z)-亚苄基)-6-((5-(叔丁基)-1H-咪唑-4-基)亚甲基)哌嗪-2,5-二酮
CAS 714272-27-2 MFCD14272272
化学结构图
SMILES: CC(C)(C)c1[nH]cnc1/C=c1/[nH]c(=O)/c(=C\c2ccccc2)[nH]c1=O
化学属性
| Mol. Weight | 336.39 |
|---|---|
| Appearance | Yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (Z)-3-((Z)-Benzylidene)-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione |
|---|---|
| Formula | C19H20N4O2 |
| Synonym | NPI 2358; NPI2358; NPI-2358; Plinabulin |
| IUPAC Name | (3E,6E)-3-benzylidene-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione |
| InChIKey | UNRCMCRRFYFGFX-AOEKMSOUSA-N |
| InChI | InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9+,15-10+ |
| Canonical SMILES | O=C(/C(NC/1=O)=C\C2=CC=CC=C2)NC1=C\C3=C(C(C)(C)C)NC=N3 |
| Chemical Name Translation | (Z)-3-((Z)-亚苄基)-6-((5-(叔丁基)-1H-咪唑-4-基)亚甲基)哌嗪-2,5-二酮 |
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产品应用
- Plinabulin is a VDA of novel structure in having been derived from a marine microbial source, as opposed to terrestrial sources for other VDAs. Plinabulin binds to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. Plinabulin has been shown to produce anti-tumor activity in animal models as a single agent and synergistically with other chemotherapy agents including taxanes. Overall, preclinical studies indicated plinabulin had a favorable safety and activity profile leading to the initiation of clinical trials. Favorable data from early clinical studies lead to the initiation of a Phase 2 clinical trial program. .
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