3-((Quinolin-4-Ylmethyl)Amino)-N-(4-(Trifluoromethoxy)Phenyl)Thiophene-2-Carboxamide 3-((喹啉-4-基甲基)氨基)-N-(4-(三氟甲氧基)苯基)噻吩-2-甲酰胺

CAS 728033-96-3 MFCD28033963

化学结构图

728033-96-3
SMILES: O=C(Nc1ccc(OC(F)(F)F)cc1)c1sccc1NCc1ccnc2ccccc12

化学属性

Mol. Weight443.44
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name3-((Quinolin-4-Ylmethyl)Amino)-N-(4-(Trifluoromethoxy)Phenyl)Thiophene-2-Carboxamide
FormulaC22H16F3N3O2S
Synonym OSI-930; OSI 930; OSI930.
IUPAC Name3-((quinolin-4-ylmethyl)amino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide
InChIKeyFGTCROZDHDSNIO-UHFFFAOYSA-N
InChIInChI=1S/C22H16F3N3O2S/c23-22(24,25)30-16-7-5-15(6-8-16)28-21(29)20-19(10-12-31-20)27-13-14-9-11-26-18-4-2-1-3-17(14)18/h1-12,27H,13H2,(H,28,29)
Canonical SMILESO=C(C1=C(NCC2=CC=NC3=CC=CC=C23)C=CS1)NC4=CC=C(OC(F)(F)F)C=C4
Chemical Name Translation3-((喹啉-4-基甲基)氨基)-N-(4-(三氟甲氧基)苯基)噻吩-2-甲酰胺
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产品应用

  • OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Protein Tyrosine Kinase
  3. c-Kit

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