Chidamide N-(2-氨基-5-氟苯基)-4-((3-(吡啶-3-基)丙烯酰氨基)甲基)苯甲酰胺
CAS 743420-02-2 MFCD43420022
化学结构图
SMILES: Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)/C=C/c2cccnc2)cc1
化学属性
| Mol. Weight | 390.41 |
|---|---|
| Mol. Formula | C22H19FN4O2 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Chidamide |
|---|---|
| CAS Number | 743420-02-2 |
| Chemical Name Translation | N-(2-氨基-5-氟苯基)-4-((3-(吡啶-3-基)丙烯酰氨基)甲基)苯甲酰胺 |
| PubChem Substance ID | 9800555 |
| InChI | InChI=1S/C22H19FN4O2/c23-18-8-9-19(24)20(12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+ |
| Synonym | CS055; CS-055; CS 055; HBI8000; HBI 8000; HBI-8000; Chidamide; Tucidinostat. N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide chidamide |
| Formula | C22H19FN4O2 |
| IUPAC Name | (E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide |
| InChIKey | WXHHICFWKXDFOW-BJMVGYQFSA-N |
| Canonical SMILES | O=C(NC1=CC(F)=CC=C1N)C2=CC=C(CNC(/C=C/C3=CC=CN=C3)=O)C=C2 |
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产品应用
- Chidamide, also known as Tucidinostat , CS055 and HBI-8000 , is a n orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells.
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