(S)-1-((S)-6-Amino-2-(((S)-1-Carboxy-3-Phenylpropyl)Amino)Hexanoyl)Pyrrolidine-2-Carboxylic Acid N-{N-[(S)-1-羧基-3-苯丙基]-L-赖氨酰}-L-脯氨酸

CAS 76547-98-3 MFCD76547983

化学结构图

76547-98-3
SMILES:

化学属性

Mol. Weight405.55
Mol. FormulaC21H31N3O5

别名和识别编码

Chemical Name(S)-1-((S)-6-Amino-2-(((S)-1-Carboxy-3-Phenylpropyl)Amino)Hexanoyl)Pyrrolidine-2-Carboxylic Acid
Synonym Zestril Lysinopril MK 0521 Lisinopril Prinivil MK 521 (S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline MK 522
Beilstein Registry Number4276619
CAS Number76547-98-3
Chemical Name TranslationN-{N-[(S)-1-羧基-3-苯丙基]-L-赖氨酰}-L-脯氨酸
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

相关文献及参考

  • [2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.
  • [1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.
  • [1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.
  • [2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.

安全信息

RTECSTW3589800 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 43 mg/kg/43W-I
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestin

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >8500 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1200 ug/kg/16D-I
TOXIC EFFECTS :
   Blood - aplastic anemia
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 346,247,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 38,1,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >8500 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Skin and Appendages - hair
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 23,2273,1989

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Angiotensin-converting Enzyme (ACE)  (血管紧张素转换酶)

相关产品推荐