NVP-BEP800 NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE

CAS 847559-80-2 MFCD47559802

化学结构图

847559-80-2
SMILES: CCNC(=O)c1cc2c(-c3cc(OCCN4CCCC4)c(Cl)cc3Cl)nc(N)nc2s1

化学属性

Mol. FormulaC21H23Cl2N5O2S
Mol. Weight480.41062
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameNVP-BEP800
Chemical Name TranslationNVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
Chemicalbook IDCB22506238
FormulaC21H23Cl2N5O2S
Synonym NVP BEP800; NVP-BEP 800; NVP BEP-800; BEP-800; BEP800; BEP 800.
IUPAC Name2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
InChIKeyWJUNQSYQHHIVFX-UHFFFAOYSA-N
InChIInChI=1S/C21H23Cl2N5O2S/c1-2-25-19(29)17-10-13-18(26-21(24)27-20(13)31-17)12-9-16(15(23)11-14(12)22)30-8-7-28-5-3-4-6-28/h9-11H,2-8H2,1H3,(H,25,29)(H2,24,26,27)
Canonical SMILESO=C(C1=CC2=C(C3=CC(OCCN4CCCC4)=C(Cl)C=C3Cl)N=C(N)N=C2S1)NCC
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产品应用

  • NVP-BEP800, also known as BEP-800, is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 showed activity against a panel of human tumor cell lines and primary human xenografts in vitro at nanomolar concentrations. In A375 melanoma and BT-474 breast cancer cell lines, NVP-BEP800 induced client protein degradation (including ErbB2, B-Raf(V600E), Raf-1, and Akt) and Hsp70 induction.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. MARK
  3. Raf

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