WP-1034
CAS 857064-42-7 MFCD57064427
化学结构图
SMILES: C[C@@H](NC(=O)/C(C#N)=C/c1ccc([N+](=O)[O-])cc1)c1ccccc1
化学属性
| Mol. Weight | 321.33 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | WP-1034 |
|---|---|
| Formula | C18H15N3O3 |
| Synonym | WP1034; WP-1034; WP 1034 |
| IUPAC Name | (R,E)-2-cyano-3-(4-nitrophenyl)-N-(1-phenylethyl)acrylamide |
| InChIKey | RYYNDHCHTCVQJH-KWWJGWKXSA-N |
| InChI | InChI=1S/C18H15N3O3/c1-13(15-5-3-2-4-6-15)20-18(22)16(12-19)11-14-7-9-17(10-8-14)21(23)24/h2-11,13H,1H3,(H,20,22)/b16-11+/t13-/m1/s1 |
| Canonical SMILES | O=C(N[C@@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=CC=C([N+]([O-])=O)C=C2 |
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产品应用
- WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP).
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