Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types.
相关文献及参考
Li, Q., et al.: J. Med. Chem., 39, 3070 (1996),
Ptasznik, A., et al.: Nat. Med., 10, 1187 (2004),
Tetsuo, A., et al.: Bioorg. Med. Chem. Lett., 16, 1421 (2006),
安全信息
Storage condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).