Belinostat 贝利司他

CAS 866323-14-0 MFCD66323140

化学结构图

866323-14-0
SMILES:

化学属性

Mol. FormulaC15H14N2O4S
Mol. Weight318.34
Appearance White Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameBelinostat
Chemical Name Translation贝利司他
Chemicalbook IDCB82628305
FormulaC15H14N2O4S
Synonym PXD 101; PXD101; PXD-101; PX105684; PX-105684; PX 105684; NSC726630; brand name: Beleodaq.
IUPAC Name(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide.
InChIKeyNCNRHFGMJRPRSK-MDZDMXLPSA-N
InChIInChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
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产品应用

  • Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. Belinostat was approved in 2014 for relapsed or refractory peripheral T-cell lymphoma.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Epigenetics
  3. HDAC
  1. Medical Research Areas
  2. Neuronal Signaling
  3. HDAC

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