TTT-3002

CAS 871037-95-5 MFCD71037955

化学结构图

871037-95-5
SMILES: CNC(=O)[C@@]1(N)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

化学属性

Mol. Weight465.5
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameTTT-3002
FormulaC27H23N5O3
Synonym TTT3002; TTT3002; TTT3002.
IUPAC Name(5R,7R,8S)-7-amino-N,8-dimethyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxamide
Canonical SMILESO=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@]6([H])O[C@@]7(C)[C@@](N)(C(NC)=O)C6)N7C8=CC=CC=C83
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产品应用

  • TTT-3002 is a tyrosine kinase inhibitor (TKI) that is one of the most potent FLT3 inhibitors discovered to date. Studies using human FLT3/ITD mutant leukemia cell lines revealed the half maximal inhibitory concentration (IC50) for inhibiting FLT3 autophosphorylation is from 100 to 250 pM. The proliferation IC50 for TTT-3002 in these same cells was from 490 to 920 pM. TTT-3002 also showed potent activity when tested against the most frequently occurring FLT3-activating point mutation, FLT3/D835Y, against which many current TKIs are ineffective.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FLT3

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