N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine N4-(5-环丙基-1H-吡唑-3-基)-N2-((3-异丙基异恶唑-5-基)甲基)-6-(4-甲基哌嗪-1-基)嘧啶-2,4-二胺

CAS 898280-07-4 MFCD98280074

化学结构图

898280-07-4
SMILES: CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1

化学属性

Mol. Weight437.54
Appearance White solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name TranslationN4-(5-环丙基-1H-吡唑-3-基)-N2-((3-异丙基异恶唑-5-基)甲基)-6-(4-甲基哌嗪-1-基)嘧啶-2,4-二胺
Chemical NameN4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
FormulaC22H31N9O
Synonym XL228; XL-228; XL 228
IUPAC NameN4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
InChIKeyALKJNCZNEOTEMP-UHFFFAOYSA-N
InChIInChI=1S/C22H31N9O/c1-14(2)17-10-16(32-29-17)13-23-22-25-19(24-20-11-18(27-28-20)15-4-5-15)12-21(26-22)31-8-6-30(3)7-9-31/h10-12,14-15H,4-9,13H2,1-3H3,(H3,23,24,25,26,27,28)
Canonical SMILESCN(CC1)CCN1C2=NC(NCC3=CC(C(C)C)=NO3)=NC(NC4=NNC(C5CC5)=C4)=C2
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产品应用

  • XL228 is a synthetic molecule that targets multiple tyrosine kinases with potential antineoplastic activity. Tyrosine kinase inhibitor XL228 binds to and inhibits the activities of multiple tyrosine kinases, such as the insulin-like growth factor 1 receptor (IGF1R), Src tyrosine kinase, and Bcr-Abl tyrosine kinase. Blockade of these kinases may result in the inhibition of tumor angiogenesis, cell proliferation, and metastasis.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Bcr-Abl
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Bcr-Abl

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