N-(3-(5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-3-Carbonyl)-2,4-Difluorophenyl)Propane-1-Sulfonamide N-(3-(5-氯-1H-吡咯并[2,3-b]吡啶-3-羰基)-2,4-二氟苯基)丙烷-1-磺酰胺

CAS 918505-84-7 MFCD018505847

化学结构图

918505-84-7
SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F

化学属性

Mol. Weight413.82
Mol. FormulaC17H14ClF2N3O3S
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

CAS Number918505-84-7
Chemical NameN-(3-(5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-3-Carbonyl)-2,4-Difluorophenyl)Propane-1-Sulfonamide
Synonym N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide PLX 4720 PLX 4720; PLX4720; PLX-4720. PLX-4720 PLX4720
Chemical Name TranslationN-(3-(5-氯-1H-吡咯并[2,3-b]吡啶-3-羰基)-2,4-二氟苯基)丙烷-1-磺酰胺
PubChem Substance ID24180719
InChIInChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
LabNetwork Molecule IDLN01313514
FormulaC17H14ClF2N3O3S
IUPAC NameN-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
InChIKeyYZDJQTHVDDOVHR-UHFFFAOYSA-N
Canonical SMILESCCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(Cl)C=C32)=O)=C1F)=O
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.

相关文献及参考

  • Conner, S., et al.: J. Biol. Chem., 278, 34548 (2003),
  • Dumaz, N., et al.: Cancer Res., 66, 9483 (2006),
  • Salerno, P., et al.: J. Clin. Endocrinol. Metab., 95, 450 (2010),

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. MARK
  3. Raf

相关产品推荐