2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid 2-(1-苄基-4-羟基-2-氧代-1,2-二氢喹啉-3-甲酰胺基)乙酸

CAS 931398-72-0 MFCD22580424

化学结构图

931398-72-0
SMILES: O=C(O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O

化学属性

Mol. FormulaC19H17N2O4
Mol. Weight352.34
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
Chemical Name Translation2-(1-苄基-4-羟基-2-氧代-1,2-二氢喹啉-3-甲酰胺基)乙酸
Chemicalbook IDCB32638323
FormulaC19H16N2O5
Synonym IOX2; IOX-2; IOX 2
IUPAC NameN-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
InChIKeyCAOSCCRYLYQBES-UHFFFAOYSA-N
InChIInChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
Canonical SMILESO=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
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产品应用

  • IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.

相关文献及参考

  • [2]. Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50.
  • [1]. Chowdhury R, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.
  • [1]. Chowdhury R, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.
  • [2]. Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. HIF
  1. Medical Research Areas
  2. Epigenetics
  3. HIF
  1. Medical Research Areas
  2. Metabolism
  3. HIF/HIF Prolyl-Hydroxylase  (缺氧诱导因子/缺氧诱导因子脯氨酸羟化酶)

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