(R)-2-Amino-7-(4-Fluoro-2-(6-Methoxypyridin-2-Yl)Phenyl)-4-Methyl-7,8-Dihydropyrido[4,3-d]Pyrimidin-5(6H)-One (R)-2-氨基-7-(4-氟-2-(6-甲氧基吡啶-2-基)苯基)-4-甲基-7,8-二氢吡啶并[4,3-d]嘧啶-5(6H)-酮

CAS 934343-74-5 MFCD034343745

化学结构图

934343-74-5
SMILES: COc1cccc(-c2cc(F)ccc2[C@H]2Cc3nc(N)nc(C)c3C(=O)N2)n1

化学属性

Mol. FormulaC20H18FN5O2
Mol. Weight379.39
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name(R)-2-Amino-7-(4-Fluoro-2-(6-Methoxypyridin-2-Yl)Phenyl)-4-Methyl-7,8-Dihydropyrido[4,3-d]Pyrimidin-5(6H)-One
Chemical Name Translation(R)-2-氨基-7-(4-氟-2-(6-甲氧基吡啶-2-基)苯基)-4-甲基-7,8-二氢吡啶并[4,3-d]嘧啶-5(6H)-酮
Chemicalbook IDCB22570378
Synonym HSP990; HSP-990; HSP 990; NVP HSP 990; NVP-HSP990; NVP HSP-990; NVP-HSP990
FormulaC20H18FN5O2
IUPAC Name(R)-2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one
InChIKeyWSMQUUGTQYPVPD-OAHLLOKOSA-N
InChIInChI=1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8,15H,9H2,1-2H3,(H,25,27)(H2,22,23,26)/t15-/m1/s1
Canonical SMILESO=C1N[C@@H](C2=CC=C(F)C=C2C3=NC(OC)=CC=C3)CC4=NC(N)=NC(C)=C41
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产品应用

  • HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.

安全信息

GHS Symbol
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Bcr-Abl
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Bcr-Abl
  1. Medical Research Areas
  2. Protein Tyrosine Kinase
  3. HER2

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