Pilaralisib 2-氨基-N-(3-(N-(3-((2-氯-5-甲氧基苯基)氨基)喹喔啉-2-基)磺胺基)苯基)-2-甲基丙酰胺
CAS 934526-89-3 MFCD034526893
化学结构图
SMILES:
化学属性
| Mol. Weight | 541.02 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 2-氨基-N-(3-(N-(3-((2-氯-5-甲氧基苯基)氨基)喹喔啉-2-基)磺胺基)苯基)-2-甲基丙酰胺 |
|---|---|
| Chemical Name | Pilaralisib |
| Formula | C25H25ClN6O4S |
| Synonym | XL147; XL 147; XL-147; SAR245408; SAR-245408; SAR 245408; Pilaralisib. |
| IUPAC Name | 2-amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide. |
| InChIKey | QINPEPAQOBZPOF-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32) |
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- Pilaralisib, also known as XL147, is a Class 1 PI3K kinase family inhibitor, and is a n orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis.
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