(S)-N-Hydroxy-4-(3-Methyl-2-Phenylbutanamido)Benzamide (S)-N-羟基-4-(3-甲基-2-苯基丁酰胺基)苯甲酰胺
CAS 935881-37-1 MFCD035881371
化学结构图
SMILES: CC(C)[C@H](C(=O)Nc1ccc(C(=O)NO)cc1)c1ccccc1
化学属性
| Mol. Weight | 312.36 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (S)-N-Hydroxy-4-(3-Methyl-2-Phenylbutanamido)Benzamide |
|---|---|
| Chemical Name Translation | (S)-N-羟基-4-(3-甲基-2-苯基丁酰胺基)苯甲酰胺 |
| Formula | C18H20N2O3 |
| Synonym | AR42; AR 42; AR-42; (S)-HDAC-42; AR-42; NSC-736012; OSU-42; OSU-HDAC-42; OSUHDAC-42 |
| IUPAC Name | (S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide |
| InChIKey | LAMIXXKAWNLXOC-INIZCTEOSA-N |
| InChI | InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1 |
| Canonical SMILES | O=C(NO)C1=CC=C(NC([C@H](C2=CC=CC=C2)C(C)C)=O)C=C1 |
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产品应用
- AR-42, also known as (S)-HDAC-42; AR-42; NSC-736012; OSU-42; OSU-HDAC-42; OSUHDAC-42, is a broad-spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies when compared in preclinical studies to vorinostat (also known as "SAHA" or Zolinza®), the first of two marketed compound in the class. AR-42 may possess additional histone-independent mechanisms, which may contribute to its superior profile in vitro and in vivo.
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