4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- N6-(4,5-二氢-4,4-二甲基-2-恶唑基)-N4-[3-甲基-4-([1,2,4]三唑[1,5-a]吡啶-7-基氧基)苯基]-4,6-喹唑啉二胺
CAS 937263-43-9 MFCD037263439
化学结构图
SMILES:
化学属性
| Mol. Formula | C26H24N8O2 |
|---|---|
| Mol. Weight | 480.53 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- |
|---|---|
| Chemical Name Translation | N6-(4,5-二氢-4,4-二甲基-2-恶唑基)-N4-[3-甲基-4-([1,2,4]三唑[1,5-a]吡啶-7-基氧基)苯基]-4,6-喹唑啉二胺 |
| Chemicalbook ID | CB32616075 |
| Formula | C26H24N8O2 |
| Synonym | ARRY380; ARRY 380; ARRY-380; ONT380; ONT 380; ONT-380. Irbinitinib; Tucatinib. |
| IUPAC Name | N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine |
| InChIKey | SDEAXTCZPQIFQM-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31) |
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产品应用
- Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
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