昂丹司琼盐酸盐 二水合物 昂丹司琼盐酸盐 二水合物
CAS 99614-01-4 MFCD99614014
化学结构图
SMILES: [2H]C1N=C(N(CC2CCC3=C(C2=O)C2C=CC=CC=2N3C)C=1[2H])C([2H])([2H])[2H]
化学属性
| Mol. Weight | 329.83(as Anhydrous) |
|---|---|
| Mol. Formula | C18H19N3O·HCl·2H2O |
| Melting Point | 176.0 to 180.0 deg-C |
别名和识别编码
| CAS Number | 99614-01-4 |
|---|---|
| Chemical Name | Ondansetron Hydrochloride |
| Synonym | 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one Hydochloride GR 38032 GR 38032X Zofran Zophren Zudan |
| Chemical Name Translation | 昂丹司琼盐酸盐 二水合物 |
| MDL Number | MFCD00374371 |
| Reaxys-RN | 7403248 |
| PubChem Substance ID | 172089079 |
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分类
- Amines
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A specific serotonin (5-HT3) receptor antagonist. Antiemetic.
相关文献及参考
- [2]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.
- [3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.
- [4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.
- [5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.
- [6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.
- Faris, P..L., et al.: Lances, 355, 792 (
安全信息
- H301 Toxic if swallowed 吞食有毒
GHS Symbol
- P301+P310+P330
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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