Bromomethane 溴甲烷

CAS 74-83-9 MFCD00000166

化学结构图

74-83-9
SMILES: CBr

化学属性

Autoignition Point996 °F
Vapor Density3.3 (20 °C, vs air)
Boiling Point3.56°C
Melting Point-93.66°C
Vapor Pressure1420 mmHg ( 20 °C)
Solubility1.522 G/100 ML
Refractive index1.4218
Flash Point-34 °C
Density0.86
Mol. FormulaCH3Br
Mol. Weight94.95
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameBromomethane
Synonym (mono)bromomethane (一)溴甲烷 1-Bromomethane BROMOMETHANE Bercema Br Brom-O-Gas Brom-O-Sol Brom-O-gas Brom-O-gaz Brom-O-sol Brom-methan Brommethan Bromometano Bromomethane Bromomethane (Methyl bromide) 100 µg/mL in Methanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number74-83-9
PubChem Substance ID6323
EC Number200-813-2
MDL NumberMFCD00000166
Beilstein Registry Number1209223
Chemical Name Translation溴甲烷
Merck Number13,6056
Wiswesser Line NotationE1
LabNetwork Molecule IDLN02127153
InChIInChI=1S/CH3Br/c1-2/h1H3
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分类

  • Aliphatic halogenated, Alkyl, Analytical Standards, Analytical/Chromatography, Building Blocks, Chemical Synthesis, Chromatography, Environmental Standards, Halogenated Hydrocarbons, Herbicides, Organic Building Blocks, Pesticides & Metabolites
  • {Chemicalbook} 农药中间体: 除草剂中间体: 除草剂中间体
  • {SNA} Aliphatic halogenated, Alkyl, Analytical Standards, Analytical/Chromatography, Building Blocks, Chemical Synthesis, Chromatography, Environmental Standards, Halogenated Hydrocarbons, Herbicides, Organic Building Blocks, Pesticides & Metabolites
  • {uni_hamburg} no charge; 1fragment

产品应用

  • 该品为熏蒸剂,可杀虫、鼠和某些病菌。也可作为木材防腐剂、制冷剂、低沸点溶剂,用于有机合成,可制一氟一氯甲烷;与氯化钴配制成增湿剂。

相关文献及参考

  • Merck: 14,6029
  • Short: II/14b
  • Merck: 14,6029 Beilstein: 1,IV,68 / Beil. 1,66
  • Short: II/14a
  • Short: II/19a

安全信息

GHS Symbol
WGK Germany3
Hazard Codes F+,Xn,N F,Xn,N T,N,Xn,F,F+ T;N
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H301+H331
  • H280 Contains gas under pressure; may explode if heated 内含高压气体,遇热可能爆炸。
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H420 Harmspublichealthandtheenvironmentbydestroyingozoneintheupperatmospere 通过破坏上层大气臭氧层而危害公众健康和环境。
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H335+H336
  • H302+H332
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSPA4900000
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P305+P351+P338
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
Signal word Danger
Safety Statements
  • S38 In case of insufficient ventilation wear suitable respiratory equipment 通风不良时,佩带适当的呼吸器;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S15 Keep away from heat 远离热源;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S24 Avoid contact with skin 避免皮肤接触;
  • S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护;
  • S59 Refer to manufacturer/supplier for information on recovery/recycling 参考生产厂家/供货商提供的回收/再生利用信息;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R12 Extremely flammable 极端易燃
  • R48/20
  • R11 Highly flammable 非常易燃
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R59 Dangerous for the ozone layer 对臭氧层有危害
  • R38 Irritating to skin 刺激皮肤
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
UN Number 1062/1581/1647/1955 UN 1062 2.3
Storage condition 冰箱2-8℃保存 2-8°C
Hazard Class2.3
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3250 mg/kg/13W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - peritonitis
   Gastrointestinal - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   72,262,1984

TYPE OF TEST            : LCLo - L

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 300 ppm/9H
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Skin and Appendages - hair
REFERENCE :
   XPHBAO U.S. Public Health Service, Public Health Bulletin.  (Washington, DC)
    Volume(issue)/page/year: 185,1,1929

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 35 ppm
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Gastrointestinal - nausea or vomiting
   Skin and Appendages - corrosive (after topical exposure)
REFERENCE :

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 1 gm/m3/2H
TOXIC EFFECTS :
   Blood - change in clotting factors
REFERENCE :
   NHOZAX Nippon Hoigaku Zasshi.  Japanese Journal of Legal Medicine.  (Nippon
   Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo,
   Bunkyo-ku, Tokyo 113, Japan)  V.1-    1944-  Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INHEAO Industrial Health.  (National Institute of Industrial Health, 6-21-1
   Nagao, Tama-ku, Kawasaki, 213 Japan)  V.1-    1963- Volume(issue)/page/year:
   26,101,1988

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : R

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 gm/m3
REFERENCE :
   MUREAV Mutation Research.

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   10,21,1990

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TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 400 ppm
REFERENCE :
   DHEFDK HEW Publication (FDA. United States).  (Washington, DC)  ?-1979(?).
   For publisher information, see HPFSDS.  Volume(issue)/page/year:
   FDA-78-1046,1978

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 8 mg/L/1H (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,131,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3 pph
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9,171,1987

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 150 mg/m3/6H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,272,1983

Restrict -

其他信息

  • 下游产品:9-乙烯基蒽 --> 2-甲基-3-羟基-4-吡喃酮 --> 二甲基二硫 --> 3-异丙基-二甲基苄基异氰酸酯TMI --> 2-甲基-4-甲胺基-6-甲氧基均三嗪 --> 嗪草酮 --> 氨甲基膦酸 --> 4,4-二甲基-2-戊酮 --> 安替比林 --> 3,3-二苯基四氢呋喃-2-亚基二甲基溴化胺 --> 1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑 --> 甲基溴化镁 --> 奥扎格雷 --> (乙酰氨基){[2-((双(2-羟乙基)氨基)甲基)-5-硝基苯基]甲基}丙二酸二乙酯 --> 泮库溴铵 --> 21-碘-16Β-甲基孕甾-1,4,9(11)三烯-17Α-醇-3,20-二酮 --> 卡莫司他 --> 3-苯酰苯基乙酸 --> 16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯 --> 溴苄乙胺 --> 16Β-甲基孕甾-1,4,9(11)-三烯-17Α-醇-3,20-二酮 --> 2-甲基-2-金刚烷醇 --> 噻托溴铵 --> 2-氯-4-乙酰吡啶 --> 溴丙胺太林 --> 9Α-溴-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-21-醋酸酯 --> 别名T402 --> 溴化新斯的明 --> 甲基三苯基溴化 --> 十八烷基三甲基溴化铵 --> 16Β-甲基孕甾-4,9(11)-二烯-17Α-醇-3,20-二酮 --> 维库溴铵
  • 使用方法:以密闭熏蒸方式防治仓贮害虫及鼠。土壤熏蒸可防治青枯病、立枯病、白绢病等植物病害及根瘤线虫。18~45克/米3熏蒸24小时可防治仓贮稻、麦、豆类等原粮及面粉、饲料、坚果、干果等的米象、谷象、谷蠹、赤拟谷盗、麦蛾、印度谷螟、豆象、谷斑皮蠹、玉米象、粉螨等害虫害螨; 含水量12%以上的种子不能熏蒸,以防影响发芽。32~50克/米3熏蒸2~4小时,可防治新鲜蔬菜、水果的玉米螟、豆荚螟等鳞翅目幼虫、金龟子、果蝇、介壳虫、叶螨、潜叶蝇等。16~50克/米3熏蒸温室植物,可防治介壳虫、蓟马、蚜虫、叶螨、白蝇、潜叶蝇、枯墨蚊等害虫及一些钻蛀性害虫。30~45克/米3熏蒸24~36小时,可防治棉、毛织品及木材蛀虫。4~6克/米3熏蒸4~5小时可灭鼠。温度高,熏蒸力强,药量要相应减少。某些活、鲜植物、果实较敏感,用药前应先做小面积试验,以防产生药害。因溴甲烷毒性较高,无特殊解毒药,使用时要注意安全。
  • 储运特性:库房通风低温干燥; 轻装轻卸; 与助燃气体分开存放
  • 蒸气密度:3.3 (20 °C, vs air)
  • 用途三:溴甲烷是除草剂苯磺隆、嗪草酮的中间体,也可以作为甲基环氧化剂生产戊唑醇、己唑醇等,并可作为熏蒸剂
  • 毒性分级:高毒
  • 类别:有害气体
  • 方法二:溴甲烷的生产方法有溴化钠法、氢溴酸法和溴素法。其中溴化钠法和氢溴酸法因原料消耗高、来源困难,生产中要使用硫酸,对设备腐蚀严重,因此,国外已不大采用。而溴素法产率高、工艺简单、基建投资少,是目前生产溴甲烷的主要方法。(1)溴素法 先由溴素与硫磺混合制备溴化硫,再将溴化硫滴加入甲醇中,在50-65℃反应,并连续蒸出反应物而得溴甲烷,反应生成的溴甲烷气体经5%烧碱液洗涤,又通入酸洗塔用硫酸洗涤,再经干燥塔用无水氯化钙干燥,最后压缩液化得产品溴甲烷。纯度可达98%以上。每吨产品消耗溴素887kg,甲醇374kg,硫磺90kg,氢氧化钠15kg。(2)氢溴酸法 由氯甲烷与氢溴酸在溴化铝存在下反应而得,收率为90%。(3)溴化钠法 采用甲醇、溴化钠和硫酸为原料,经反应而得:工艺过程如下:向衬铅或搪瓷反应锅中先加入溴化钠,用管道压入硫酸、甲醇,从夹套通入蒸汽加热,当反应温度升到60℃时,即适当控制反应速度,溴甲烷气体离开反应锅后,经紫铜冷凝器冷却再进入碱水(5%NaOH)洗涤塔去酸,再去硫酸干燥塔去水,经压缩至0.98MPa即得成品。原料消耗定额:溴化钠1100kg/t、甲醇40kg/t、硫酸1960kg/t。 用途:该品为熏蒸剂,可杀虫、鼠和某些病菌。本品沸点低,可直接打开钢瓶阀门,
  • 方法一:其制备有两种生产工艺。 (1)溴化钠法 在反应釜中加入溴化钠和硫酸甲醇,夹套蒸汽加热,当反应温度为60℃时控制反应速度,蒸出溴甲烷,经碱水(5%NaOH)洗涤塔去酸,再经干燥塔干燥脱水,经压缩即得成品。 CH 3 OH

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