2',4'-Dichloroacetophenone 2,4-二氯苯乙酮

CAS 2234-16-4 MFCD00000581

化学结构图

2234-16-4
SMILES: CC(=O)c1ccc(Cl)cc1Cl

化学属性

Mol. FormulaC8H6Cl2O
Mol. Weight189.04
Density1.320
Refractive indexn20/D 1.5635(lit.)
Flash Point113°C
TSCAYes
Boiling Point246.7°C at 760 mmHg
Melting Point33-34°C
SolubilityCA. 200 MG/L
Appearance 1.5635,不溶于水,溶于苯、甲苯、醇等有机溶剂。 2,4-二氯苯乙酮为白色结晶体,m.p.33~34℃,b.p.128~131℃/2.4kpa,n D 20

别名和识别编码

Chemical Name2',4'-Dichloroacetophenone
CAS Number2234-16-4
Alfabeta NameDICHLOROACETOPHENONE 24-,''
MDL NumberMFCD00000581
EC Number218-780-8
Beilstein Registry Number637819
PubChem Substance ID16693
Synonym 2',4'-Dichloroacetophenone {LY} 2',4'-Dichloroacetophenone {} {LY} 2',4'-Dichloroacetophenone {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation2,4-二氯苯乙酮
Reaxys-RN637819
LabNetwork Molecule IDLN00174552
InChIInChI=1S/C8H6Cl2O/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,1H3
Canonical SMILESC1=C(C(=CC=C1Cl)C(C)=O)Cl
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分类

  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 三唑类杀菌剂
  • {SNA} Building Blocks, C7 to C8, Carbonyl Compounds, Chemical Synthesis, Ketones, Organic Building Blocks

安全信息

Warnings IRRITANT
Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R52/53
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P308+P313
  • P332+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P302+P350
  • P337+P313
  • P305+P351+P338
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xn,Xi
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • Acros Organics:2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone, 98.50%(2234-16-4)
  • Alfa Aesar:2',4'-二氯苯乙酮,98% 2',4'-Dichloroacetophenone, 98%(2234-16-4)
  • 下游产品:伊曲康唑
  • 用途一:用作医药中间体,用于合成酮康唑药物
  • Hazard Note:Irritant
  • 2,4-二氯苯乙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1490 2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone 500G 2090元 2014/06/02 D1490 2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone 25G 502元 2010/06/21 302430250 2,4-二氯苯乙酮 2',4'-Dichloroacetophenone 97% 25 GR 471元
  • 图谱信息:2,4-二氯苯乙酮(2234-16-4)质谱(MS) 2,4-二氯苯乙酮(2234-16-4)红外图谱(IR1) 2,4-二氯苯乙酮(2234-16-4)核磁图( 1 HNMR) 2,4-二氯苯乙酮(2234-16-4)Raman光谱 2,4-二氯苯乙酮(2234-16-4)核磁图( 13 CNMR)
  • MOL 文件:2234-16-4.mol
  • TCI Shanghai:2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone,>;98.0%(GC)(2234-16-4)
  • MSDS 信息:2',4'-Dichloroacetophenone(2234-16-4).msds
  • 方法一:其制备方法是在反应瓶中加入间二氯苯,升温至50℃,搅拌下加入适量的无水三氯化铝,保持温度50℃,滴加乙酰氯,滴完后逐渐升温至100℃,并在该温度下搅拌8h,反应结束后,在反应液中加入二氯甲烷并倒入水中,放置冷却,分出油层,水层用二氯甲烷萃取,并入有机层,用水洗涤有机层,干燥,蒸去溶剂减压蒸馏,收集160~180℃/0.015 MPa馏分,得到白色结晶为2,4-二氯苯乙酮。
  • 用途二:2,4-二氯苯乙酮是制备ω-溴-2,4-二氯苯乙酮或ω-2,4-三氯苯乙酮的原料,后两者是制备抑霉唑、丙环唑、乙环唑等杀菌剂的中间体,也是杀虫剂毒虫畏、除草剂野燕枯的中间体。
  • 上游原料:二氯甲烷 --> 三氯化铝 --> 乙酰氯 --> 1,3-二氯苯
  • 用途三:酮康唑的中间体。

系列性分类


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