Hexachloroethane 六氯乙烷

CAS 67-72-1 MFCD00000799

化学结构图

67-72-1
SMILES: ClC(Cl)(Cl)C(Cl)(Cl)Cl

化学属性

Mol. FormulaC₂Cl₆
Mol. Weight236.74
Melting Point>180°C (dec.)
Density2.091
TSCAYes
Vapor Density8.16 (vs air)
Vapor Pressure0.4 mmHg ( 20 °C)
Solubility0.05 G/L (22 ºC)
Boiling Point
pH:A

别名和识别编码

Chemical NameHexachloroethane
Synonym 1,1,1,2,2,2-Hexachloroethane Avlothane C2Cl6 CCl3CCl3 Distopan Distopin Egitol Ethylene hexachloride Falkitol Fasciolin HCE Hexachlor-aethan Hexachlorethane Hexachloroethane {uni_hamburg} ethane, hexachloro- ethylenehexachloride hexachloro-ethane hexachloroethane {} {Chemicalbook} caswellno.479 {} {} {uni_hamburg} carbon hexachloride {} {} {} {uni_hamburg} Phenohep {} {} {} {} {uni_hamburg} Perchlorethan {} {} {} {} {} {hazard_com} NCI-C04604 {} {} {} {} {} {} {uni_hamburg} Hexachloräthan {} {} {} {} {} {} {} {uni_hamburg} Hexachloroethylene 全氯乙烷 六氯乙烷 六氯乙烷, 99% 六氯化三碳 六氯化碳 过氯乙烷
MDL NumberMFCD00000799
CAS Number67-72-1
EC Number200-666-4
Merck Number4679
Beilstein Registry Number1740341
PubChem Substance ID87570512
Reaxys-RN1740341
Chemical Name Translation六氯乙烷
Wiswesser Line NotationGXGGXGGG
LabNetwork Molecule IDLN00223396
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分类

  • {SNA} Analytical Standards, Food and Cosmetic Component Standards, Organic Pollutant Standards, Standards for Personal Care and Cosmetic Products, Volatiles & Semivolatiles, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards, Alpha Sort, Analytical Stand
  • {SNA} Alkyl, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, Organic Building Blocks
  • {SNA} Analytical Standards, F-L, Food and Cosmetic Component Standards, Organic Pollutant Standards, Standards for Personal Care and Cosmetic Products, Volatile & Semivolatile Standards, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱

产品应用

  • 溶剂，防腐剂。

相关文献及参考

  • In the presence of Dichlorotris(triphenyl­phosphine)­ruthenium(II)­, L00373, alkenes undergo selective dichlorination; other groups are unaffected: Tetrahedron Lett., 35, 737 (1994).
  • Short: II/27B
  • Short: II/25B
  • Merck: 14,4679
  • Merck: 14,4679 Beilstein:1,87
  • Alternative to CCl4 (ozone depleter) as a source of Cl in the chlorodehydroxylation of alcohols in the presence of PPh3. See also 1,2-Bis(diphenyl­phosphino)­ethane, A11419. Source of Cl, e.g. in reactions of aryllithiums to give the regiospecifically chloro-substituted derivatives: Tetrahedron Lett., 36, 881 (1995).

安全信息

RTECSKI4025000
Safety Statements
  • S7 Keep container tightly closed 保存在严格密闭容器中；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Packing GroupIII
UN Number UN3077 UN 9037 9037
Risk Statements
GHS Symbol
WGK Germany3
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H315 Causes skin irritation 会刺激皮肤
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H303 May be harmfully swallowed 吞食可能有害
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P305+P351+P338
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P332+P313
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P305+P351+P338+P337+P313
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P337+P313
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
Signal word
Hazard Codes
Storage condition 2-8°C 20 密封保存
Hazard Class9
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-68,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-68,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10300 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-361,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,902,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 4970 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   40,187,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 325 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   7,205,1934

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   40,187,1979

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 330 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,157,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5500 mg/kg
SEX/DURATION            : female 6-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   40,187,1979

Restrict 危险品

其他信息

  • TCI Shanghai:六氯乙烷 Hexachloroethane,>;99.0%(GC)(67-72-1)
  • 毒性分级:中毒
  • 储运特性:库房通风低温干燥; 与食品添加剂分开存放
  • 六氯乙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80068128 六氯乙烷;全氯乙烷;六氯化碳;过氯乙烷;六氯化二碳 500g 28.1元 2011/04/16 H0060 六氯乙烷 Hexachloroethane 25G 146元 2011/04/16 H0060 六
  • Sigma Aldrich:67-72-1(sigmaaldrich)
  • 用途三:溶剂，防腐剂。该品用作溶剂和用于生产氟里昂-113、农药、医药、兽药、发烟剂、除泡剂、铝制品的脱气剂、脱氧剂（铝、镁、铜及其合金）、切消油添加剂以及聚氯乙烯助增塑剂、有机合成中间体。六氯乙烷与锌粉、氯化铵、过氯酸铵等按比例混合可用作烟雾生成剂，六氯乙烷还用作樟脑代用品和橡胶硫化促进剂等。六氯乙烷本身也是一种兽用驱虫药。主要用于反刍兽肝蛭病及胃蛭病，其他睾吸虫病和线虫病等。
  • 防护措施:本品是氯代烃中毒性最大的一种，对人的中枢神经有毒害作用。常温时蒸气浓度小，故对肝、肾的毒性小。狗静脉注射MLD325mg/kg。空气中最高容许浓度1ppm。 生产设备应密闭。生产现场保持良好通风。操作人员应戴防护用具。
  • 用途一:用作润滑油添加剂，亦可用于制造杀虫剂、驱虫剂、烟幕等
  • 方法一:由四氯乙烷经氯化而得。将脱水后的四氯乙烷投入搪玻离反应锅，在强光照射下通入氯气，反应温度逐渐上升，最后保持在90-100℃。当反应液由浑转清，通氯管出现结晶时，氯化即到达终点。停止通氯，提高温度至120℃，排出锅内余氯到达终点。停止通氯，提出高温度至120℃，排出锅内余氯。出料至盛有沸水的结晶锅内，用热水洗涤，再加1%碳酸钠和5%尿素溶液搅拌除氯。用水充分洗涤后后冷却结晶，离心过滤，最后将结晶浸泡于蒸馏水中再甩干，于40℃干燥、粉碎即得六氯乙烷。工业上也采用三氯乙烯与氯气进行光氯化。三氯乙烯与氯气发生光氯化反应生成五氯乙烷，再与液碱作用生成四氯乙烯。四氯乙烯与液氯（1：0.213）经光氯化反应制得粗制品，再经纯碱液中和、水洗、冷却结晶、离心过滤、干燥，粉碎而得成品。用此法生产六氯乙烷，每吨产品消耗三氯乙烯680kg，液氯700kg。另外，四氯化碳在氯化铝存在下与氯气反应，或乙烯在300-350℃，与氯反应都可制得该品。
  • 急性毒性:口服-大鼠 LD50：4460 毫克/公斤； 腹腔-小鼠 LD50：4500 毫克/公斤
  • MSDS 信息:六氯乙烷(67-72-1).msds
  • 可燃性危险特性:不燃
  • {Chemicalbook
  • 类别:农药
  • 六氯乙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80068128 六氯乙烷;全氯乙烷
  • 职业标准:TWA 10 毫克/立方米； STEL 30 毫克/立方米
  • Acros Organics:六氯乙烷 Hexachloroethane, 99%(67-72-1)
  • MOL 文件:67-72-1.mol
  • Alfa Aesar:六氯乙烷,99% Hexachloroethane, 99%(67-72-1)
  • 蒸气密度:8.16 (vs air)
  • 用途二:该品用作溶剂和用于生产氟里昂-113、农药、医药、兽药、发烟剂、除泡剂、铝制品的脱气剂、脱氧剂（铝、镁、铜及其合金）、切消油添加剂以及聚氯乙烯助增塑剂、有机合成中间体。六氯乙烷与锌粉、氯化铵、过氯酸铵等按比例混合可用作烟雾生成剂，六氯乙烷还用作樟脑代用品和橡胶硫化促进剂等。六氯乙烷本身也是一种兽用驱虫药。主要用于反刍兽肝蛭病及胃蛭病，其他睾吸虫病和线虫病等。
  • 外观性质:无色结晶，有樟脑样气味。
  • 灭火剂:雾状水、泡沫、二氧化碳、砂土。
  • 蒸气压:0.4 mm Hg ( 20 °C)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkyl 烷基卤代烃
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. E-L - Alpha Sort
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. H - Alphabetic
  5. HA -HT - H
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkenyl

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