Dichloroacetyl chloride 二氯乙酰氯

CAS 79-36-7 MFCD00000840

化学结构图

79-36-7
SMILES: O=C(Cl)C(Cl)Cl

化学属性

Mol. FormulaC2HCl3O
Mol. Weight147
Density1.532
Refractive index1.4590 to 1.4620
Flash PointNone
TSCAYes
Boiling Point
SolubilityMAY DECOMPOSE
Melting PointNo Data Available

别名和识别编码

Chemical NameDichloroacetyl chloride
Synonym 2,2-DICHLOROACETYL CHLORIDE 2,2-dichloroacetyl 2,2-dichloroacetylchloride[qr] Acetyl chloride, dichloro- Acetylchloride,dichloro- Chlorure de dichloracetyle DICHLOROACETYL CHLORIDE DICHLOROETHANOYL CHLORIDE Dichloracetylchlorid Dichloroacethyl chloride Dichloroacetic acid chloride Dichloroacetyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number79-36-7
EC Number201-199-9
Beilstein Registry Number2,204
MDL NumberMFCD00000840
Merck Number3053
PubChem Substance ID87567008
Reaxys-RN1209426
Chemical Name Translation二氯乙酰氯
Wiswesser Line NotationGYGVG
LabNetwork Molecule IDLN00226452
InChIInChI=1S/C2HCl3O/c3-1(4)2(5)6/h1H
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分类

  • {uni_hamburg} no charge; carbonyl chloride; 1fragment
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

产品应用

  • 用于乙烯基杀虫剂的合成,还用于羊毛毡缩绒整理;漂白;脱色;保鲜;杀菌;消毒等。

相关文献及参考

  • Merck: 14,3053
  • Short: II/27B
  • Short: II/25B
  • Merck: 14,3053 Beilstein:2,204

安全信息

Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R35 Causes severe burns 会导致严重灼伤
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P304+P340
  • P304+P340+P310
  • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P303+P361+P353+P310+P363
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
RTECSAO6650000
Packing GroupII
UN Number UN1765 1765
Storage condition +4°C 4 4℃ Moisture Sensitive 密封保存
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes C,N
Hazard Class8
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg/80W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,159,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 650 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19(Suppl 21),2,1992

Restrict 危险品

其他信息

  • MOL 文件:79-36-7.mol
  • 毒性分级:中毒
  • 用途一:用于有机合成及农药、医药中间体
  • Sigma Aldrich:79-36-7(sigmaaldrich)
  • 用途三:用于乙烯基杀虫剂的合成,还用于羊毛毡缩绒整理、漂白、脱色、保鲜、杀菌、消毒等。
  • TCI Shanghai:二氯乙酰氯 Dichloroacetyl Chloride,>;98.0%(GC)(T)(79-36-7)
  • 可燃性危险特性:遇明火、高热、氧化剂可燃; 受热或遇水、酸分解有毒氯化物气体
  • 灭火剂:砂土、二氧化碳
  • 用途二:用作有机合成中间体
  • Alfa Aesar:二氯乙酰氯,97% Dichloroacetyl chloride, 97%(79-36-7)
  • MSDS 信息:2,2-二氯乙酰氯(79-36-7).msds
  • 能与乙醚混溶,遇水和醇会分解。在空气中会发烟。
  • Acros Organics:二氯乙酰氯 Dichloroacetyl chloride, 97%(79-36-7)
  • 二氯乙酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80045226 二氯乙酰氯(*) 100ml 160.3元 2011/04/16 D0313 二氯乙酰氯 Dichloroacetyl Chloride 500G 603元 2011/04/16 D0313 二氯乙酰氯 Dichloroacetyl Chloride 25G 160元
  • 类别:腐蚀物品
  • 刺激数据:皮肤- 兔子 10 毫克/ 24小时 中度; 眼- 兔子 50 微克 重度
  • 急性毒性:口服- 大鼠 LD50: 2460 毫克/ 公斤
  • Hazard Note:Corrosive/Moisture Sensitive
  • 用途四:用于乙烯基杀虫剂的合成,还用于羊毛毡缩绒整理;漂白;脱色;保鲜;杀菌;消毒等。
  • 上游原料:三氯化铝 --> 氯磺酸 --> 氧 --> 偶氮二异丁腈 --> 三氯乙烯 --> 二氯乙酸
  • 外观性质:发烟液体, 有刺激性气味。
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 下游产品:杀虫畏 --> 三氯乙酰氯 --> 庚烯磷 --> 氟咯草酮 --> 4-羟基-3-甲基苯乙酮
  • 敏感性:Moisture Sensitive
  • F:19-21
  • 图谱信息:二氯乙酰氯(79-36-7)质谱(MS) 二氯乙酰氯(79-36-7)核磁图( 13 CNMR) 二氯乙酰氯(79-36-7)红外图谱(IR1) 二氯乙酰氯(79-36-7)核磁图( 1 HNMR)
  • 方法一:制备方法中可采用多种工艺路线。二氯乙酸与氯磺酸的反应,氯仿与一氧化碳在无水三氯化铝催化下反应,二氯乙酸与光气在二甲基甲酰胺中反应,以及用三氯乙烯氧化等都可制得该品。三氯乙烯与偶氮二异丁腈(催化剂)加热至100℃,通入氧气,在0.6MPa压力下反应,维持油浴温度在110℃,反应10h,于常压下蒸出产品二氯乙酰氯。本反应副产物三氯环氧乙烷与甲胺、三乙胺、吡啶等胺类化合物反应亦可转化为二氯乙酰氯。

系列性分类


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