• 原料直供
• 试剂商城
• 直接询价

分类

• {Chemicalbook} 农药中间体: 除草剂中间体: 酰胺类除草剂
• Chemical Synthesis, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
• {uni_hamburg} no charge; 1fragment
• {SNA} Chemical Synthesis, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents

产品应用

• A chloroalkyl ether that is an efficient alkylating agent. Used as an alcohol protecting group in the preparation of various organic compounds. A known human carcinogen.

相关文献及参考

• Lewis, D.F.V. et al.: Human Exp. Toxicol., 21, 115 (2002); Van Duuren, B.L.: Environ. Res., 49, 143 (1989);
• 1. Organometallics 25 , 4909, (2006)
• Merck 14 ,2146
• Beil. 1 ,580
• Fieser 1 ,132 / Fieser 4 ,83 / Fieser 5 ,120 / Fieser 6 ,109 / Fieser 7 ,61 / Fieser 9 ,107 / Fieser 12 ,116 / Fieser 13 ,76
• Aldrich MSDS 1 , 417:C / Corp MSDS 1 (1), 804:B / IR-Spectra (3), 126:E / IR-Spectra (2), 115:H / NMR-Reference 2 (1), 178:B / RegBook 1 (1), 215:A / Sax 6 , 738 / Structure Index 1 , 29:A:8
• Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-11365-2 Internet Resource: DOI:10.1007/b19966 RefComment: 196 figs., XI
• Short: II/24B Title: Molecular Constants mostly from Microwave, Molecular Beam, and Sub-Doppler Laser Spectroscopy: Rotational, Centrifugal Distortion and Related Constants of Diamagnetic Asymmetric Top Molecules Author: Demaison, J.; Vogt, J.; Wlodarczak, G. Editor: Hüttner, W. Source: Landolt-Börnstein, New Series Volume: II/24B Year: 2000 Keyword: Diamagnetics Diatomics; Linear Symmetric Rotors; Molecular Constants; Molecules ISBN: 3-540-65345-7 ISBN: 978-3-540-65345-5 Internet Resource: DOI:10.1007/b58835 RefComment: VIII, 525 pages. Hardcover Abstract: Volume II/24 presents the spectroscopic data on diamagnetic and paramagnetic molecules as well as on molecular ions and radicals up to date considering the publications up to and partly including 1997. The spectroscopic information collected in this volume has been obtained principally from gas phase microwave measurements. Vo

安全信息

GHS Symbol

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 ppm/6H/72W
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Endocrine - tumors
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   30,70,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 ppm/82D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   22,663,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   46,143,1971

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 55 ppm/7H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   30,61,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 65 ppm/7H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - hemorrhage
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   30,61,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1030 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,89,1982

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mL/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   13,213,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 10 mg/L
REFERENCE :
   AETODY Advances in Modern Environmental Toxicology.  (Senate Press, Inc.,
   P.O. Box 252, Princeton Junction, NJ 08550)  V.1-    1980-
   Volume(issue)/page/year: 1,241,1980

其他信息

• 外观性质:无色或微黄色液体，带有刺激性气味。
• 灭火剂:干粉、二氧化碳、泡沫、1211灭火剂
• 可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生有毒氯化物烟雾
• 方法二:在氯化钙存在下，将氯化氢气体通入甲醇和甲醛的混合液中，在略高于室温的条件下发生醇醛缩合和加成反应而得。向氯化氢发生釜中加入工业盐酸（副产氯化氢尾气亦可），在70℃下滴加硫酸（92%），将发生的氯化氢气体通入装有甲醇、甲醛溶液的反应釜中进行氯化。反应温度控制在40℃以下，甲醇（98%）与甲醛（37%）的重量比为1：2.39。当反应釜吸收氯化氢饱和后，氯化反应完毕。然后静置分层1h，其上层为合成的氯甲醚，下层为酸层，最后将氯甲醚与酸层分离。氯甲醚收率为78%。原料消耗定额：甲醇（98%）0.5t/t、甲醛（37%）1.2t/t、硫酸（92%）3.5t/t、盐酸（33%）2.6t/t。
• 图谱信息:氯甲基甲醚(107-30-2)红外图谱(IR1) 氯甲基甲醚(107-30-2)核磁图( 13 CNMR) 氯甲基甲醚(107-30-2)核磁图( 1 HNMR) 氯甲基甲醚(107-30-2)质谱(MS)
• 毒性分级:中毒
• 上游原料:甲醛 --> 工业盐酸 --> 三聚甲醛
• MSDS 信息:氯甲基甲醚(107-30-2).msds
• 下游产品:甲草胺 --> 4-氯甲基苯乙烯 --> 聚砜阴离子交换膜 --> N,N-二甲基-N-十八烷氧基亚甲基甜菜碱 --> 聚苯乙烯型聚乙烯均相阴离子交换膜 --> (甲氧基甲基)三苯基氯化 --> 红色基KL
• 类别:易燃液体
• 急性毒性:吸入-大鼠 LC50:55 PPM/7小时; 吸入-小鼠 LC50:1030 毫克/立方米/2小时
• 储运特性:库房通风低温干燥; 与氧化剂分开存放
• 职业标准:TWA 0.3 毫克/ 立方米; STEL 0.5 毫克/ 立方米
• 蒸气压:3.55 psi ( 20 °C)
• 用途一:氯甲基甲基醚是除草剂甲草胺的中间体。
• 方法一:其制备方法是在反应釜中加入一定量的甲醇和三聚甲醛，在搅拌下通入氯化氢气体，并控制一定温度，通入一定量氯化氢后控制分析氯甲基甲基醚含量，通氯化氢结束，静置分层，下层为盐酸，上层为氯甲基甲基醚，蒸馏得产品。 3CH 3 OH+(CH 2 O) 3 +3HCl→3ClCH 2 OCH 3 +3H 2 O
• Sigma Aldrich:107-30-2(sigmaaldrich)
• 爆炸物危险特性:遇热， 火源可爆炸
• MOL 文件:107-30-2.mol
• 用途二:活泼的有机中间体。氯甲基化剂，主要用于生产阴离子交换树脂，还用于生产磺胺嘧啶药物等。