Ethyl Diazoacetate 重氮乙酸乙酯

CAS 623-73-4 MFCD00001989

化学结构图

623-73-4
SMILES: CCOC(=O)C=[N+]=[N-]

化学属性

Mol. FormulaC4H6N2O2
Mol. Weight114.10
Refractive indexn20/D 1.505
Boiling Point140-141
Density1.085
Melting Point-22
Flash Point46 ºC
Solubility微溶于水,可混溶于乙醇、乙醚。

别名和识别编码

Chemical NameEthyl Diazoacetate
Synonym Ethyl diazoacetate 重氮醋酸乙酯 ETHYL DIAZOACETATE Diazoessigsaeure-aethylester Diazoacetic acid ethyl Ethyldiazoacetate Daae EDA Ethyl 2-diazoacetate ETHYL DIAZOACETATE ETHYL DIAZOETHANOATE 重氮乙酸乙酯 溶液 Diazoessigester DAAE Acetic acid, diazo-, ethyl ester Diazoessigsäureethylester diazoaceticester Diazoacetic ester Diazoessisäureethylester 重氮乙酸乙酯 Diazoacetic acid ethyl ester diazo-aceticaciethylester Ethylene Diazo Acetate 2-Diazoacetic acid ethyl Diazoessigsäure-ethylester diazoaceticacid,ethylester Ethyl diazoethanoate Diazo-acetic acid ethyl ester 2-Diazoacetic acid ethyl ester solution Ethoxycarbonyldiazomethane Diazoacetic acid, ethyl ester
CAS Number623-73-4
PubChem Substance ID12192
Beilstein Registry Number107654
MDL NumberMFCD00001989
EC Number210-810-8
Chemical Name Translation重氮乙酸乙酯
Merck Number13,3021
Wiswesser Line NotationNNU1VO2
LabNetwork Molecule IDLN00110695
InChIInChI=1S/C4H6N2O2/c1-2-8-4(7)3-6-5/h3H,2H2,1H3
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分类

  • {uni_hamburg} no charge; ester; 1fragment
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 拟除虫菊酯类杀虫剂
  • {SNA} Azo/Diazo Compounds, Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
  • Azo/Diazo Compounds, Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 用于有机合成,是钌催化的烯烃的不对称环烷化试剂。

相关文献及参考

  • Merck: 14,2997 Beilstein: 3,IV,1495
  • Short: IV/1a
  • Short: III/35E
  • Merck: 14,2997

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H351 Suspected of causing cancer 怀疑致癌
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Hazard Codes F,Xn
Precautionary statements
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Safety Statements
  • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
Risk Statements
  • R10 Flammable 易燃
  • R5 Heating may cause an explosion 加热会引起爆炸
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R22 Harmful if swallowed 吞咽有害
  • R11 Highly flammable 非常易燃
  • R38 Irritating to skin 刺激皮肤
  • R48/20
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
UN Number
Storage condition 储存温度 2-8°C 2-8°C
Warnings 危化品目录(2015)
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,785,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg/30W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 55,117,1985

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg/68W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   50,99,1963

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4300 mg/kg/86W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   ADRCAC Annali Italiani di Dermatologia Clinica e Sperimentale.  (Clinica
   Dermosifilopatica Universita degli Studi, Policlinica Monte

TYPE OF TEST            : TD - Toxic dose (other than

RTECSAG5775000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 135,219,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   XENOBH Xenobiotica.  (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
   UK)  V.1-    1971-  Volume(issue)/page/year: 3,271,1973

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其他信息

  • 生产方法:由甘氨酸乙酯盐酸盐与亚硝酸钠反应而得。
  • MOL 文件:623-73-4.mol
  • NIST化学物质信息:Ethyl diazoacetate(623-73-4)
  • 外观性质:黄色油状液体, 有辛辣的气味。
  • 溶于乙醇、苯、乙醚,微溶于水,有辛辣气味,易挥发,有爆炸性,与硫酸接触,甚至减压蒸馏时也会发生爆炸。
  • HazardClass:3.2
  • RTECS号:AG5775000
  • PackingGroup:III
  • 用途:重氮乙酸乙酯是制备菊酸或二氯菊酸的重要中间体。

系列性分类


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