Toluene-2,4-Diisocyanate 二异酸甲苯酯
CAS 584-84-9 MFCD00002011
化学结构图
SMILES: Cc1ccc(N=C=O)cc1N=C=O
化学属性
| Mol. Formula | C9H6N2O2 |
|---|---|
| Mol. Weight | 174.16 |
| Boiling Point | 251°C(lit.) |
| Density | 1.214 g/mL at 25 °C |
| Melting Point | 20-22 °C (lit.) |
| Refractive index | n20/D 1.568(lit.) |
| Flash Point | 132° (270°F) |
| TSCA | Yes |
| Autoignition Point | >;1148 °F |
| Vapor Density | 6 (vs air) |
| Vapor Pressure | 0.03 mmHg ( 25 °C) |
| Solubility | 起反应 |
别名和识别编码
| Chemical Name | Toluene-2,4-Diisocyanate |
|---|---|
| CAS Number | 584-84-9 |
| Synonym | 2,4-二异氰酸酯 Hylene T Tolylene 2,4-diisocyanate SCURANATE T100 甲苯-2，4-二异氰酸酯 2，4-二异氰酸甲苯酯 2,4-二异酸甲苯酯 甲苯二异氰酸酯 2,4-TDI NCI 2,4-Toluylendiisocyanat SCURANATE TX 2,4-二异氰酸基甲苯 2,4-Diisocyan Tolylene-2,4-diisocyanate ######## Isocyanic acid, methylphen 1-METHYL-1,3-PHENYLENE DIISOCYA {Chemi TOLYLENE-2,4-DIISOCYANATE 4-Methyl- 2,6-Diisocyanat-toluol { C9H6N2O2 (2,4-diisocyanato-1-methyl-benzene) NSC 56759 4-Methyl-m-phenylene diisocyante TDI-80 2,4-Toluoldiisocyanat 甲代亚苯基 |
| PubChem Substance ID | 87576243 |
| EC Number | 209-544-5 |
| Beilstein Registry Number | 13,138 |
| MDL Number | MFCD00002011 |
| Merck Number | 9530 |
| Chemical Name Translation | 二异酸甲苯酯 |
| Wiswesser Line Notation | OCNR B1 ENCO |
| LabNetwork Molecule ID | LN00195034 |
| InChI | InChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3 |
| Reaxys-RN | 744602 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Air Monitoring Standards, Alphabetic, Analytical Standards, Analytical/Chromatography,
- {SA} Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Aromatics, Carbohydrate Chemistry, Carbohydrate Derivatives, Chemical Biology, Chemical Class,
产品应用
- Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. Toluene-2,4-diisocyanate (TDI) is one of the most common respiratory sensitizers leading to occu
相关文献及参考
- Vanoirbeek, J., et al.: Toxicol. Sci., 2004, 80, 310 (2004),
- Crameri, R., et al.: Allergy, 60, 1227 (2005),
- Ku, H., et al.: Toxicol. Lett., 190, 231 (2009),
- 1. Biomaterials 16 , 51, (1995) 摘要
- 2. J. Incl. Phenom. Mol. Recog. Chem. 17 , 249, (1994)
- Merck 14 ,9530
- Beil. 13 ,IV,243
- Fieser 1 ,1171
- Aldrich MSDS 1 , 1720:A / Corp MSDS 1 (2), 3376:B / FT-IR 2 (2), 3199:B / FT-IR 1 (2), 478:B / IR-Spectra (3), 1144:B / IR-Spectra (2), 996:G / NMR-Reference 2 (2), 446:B / RegBook 1 (2), 2169:F / Sax 6 , 1083 / Sigma FT-IR 1 (2), 934:D / Structure Index 1 , 341:D:5 / Vapor Phase 3 , 1434:D
- Short: III/35D2 Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Carbon-13, Part 2: Aromatic Compounds Author: Mikhova, B. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35D2 Year: 2005 Keyword: aromatic compounds; carbon-13; chemical shift; coupling constant; molecular structure ISBN: 978-3-540-20189-2 ISBN: 3-540-20189-0 Internet Resource: DOI:10.1007/b83345 RefComment: VIII, 291 p., Hardcover RefComment: Written for Science and engineers in the fields of physics, chemistry and physical chemistry who inted to use NMR to study the structure and the binding of molecules Abstract: Nuclear Magnetic Resonance (NMR) is based on the fact that certain nuclei exhibit a magnetic moment, orient by a magnetic field, and absorb characteristic frequencies in the radiofrequency part of the spectrum. The spectral lines of the nuclei are highly influenced by the chemical environment i.e. the structure and interaction of the molecules. NMR is now the leading technique and a powerful tool for the investigation of the structure and interaction of molecules. The present Landolt-Börnstein volume III/35 Nuclear Magnetic Resonance (NMR) Data is therefore of
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H319 Causes serious eye irritation 严重刺激眼睛
- H330 Fatal if inhaled 吸入致命
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H351 Suspected of causing cancer 怀疑致癌
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P302+P352+P333+P313+P362+P364
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P337+P313
- P308+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P342+P311
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R52/53
- R26 Very toxic by inhalation 吸入极毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R42/43
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07807
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >16 mL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/8/1973
TYPE OF TEST : TCLo - Lowest published toxic co
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 13 ppm/4H TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - pleu
TYPE OF TEST :
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 300 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987
TYPE OF TEST : Specific locus test TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 75 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 17,196,1991
其他信息
- 甲苯-2,4-二异氰酸酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80130981 甲苯-2，4-二异氰酸酯（剧毒） 250ml 800元 2011/08/23 80130928 甲苯-2，4-二异氰酸酯（剧毒） 500ml 200元 2011/08/23 80130960 甲苯-2，4-二异氰酸酯（剧毒） 500ml 200元
- 灭火剂:泡沫、雾状水、二氧化碳、砂土、干粉。禁用酸碱灭火剂。
- 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂、酸类碱类分开存放
- 常规方法:采用镀锌铁桶包装，每桶净重35kg。贮存在通风、干燥处。包装要密闭，避免吸潮。按有毒危险品规定贮运。
- 外观性质:无色到淡黄色透明液体。
- 方法一:由甲苯硝化生成二硝基甲苯，再经还原得到甲苯二胺。甲苯二胺与光气反应即得TDI（以2,4-异构体为主）。
- 蒸气密度:6 (vs air)
- 可燃性危险特性:明火可燃;高热分解有毒氮氧化物气体
- 急性毒性:吸入- 大鼠 LC50: 98 毫克/ 立方米/4小时; 吸入- 小鼠 LC50: 70 毫克/立方米/ 4小时
- 爆炸物危险特性:与空气混合可爆
- 类别:有毒物品
- 毒性分级:剧毒
- 职业标准:TLV-TWA 0.005 PPM(0.036毫克/立方米); STEL 0.02 PPM(0.14 毫克/立方米); CL 0.02PPM (0.14 毫克/ 立方米)
- MSDS 信息:甲苯-2,4-二异氰酸酯(584-84-9).msds
- 海关编码:29291010
- 上游原料:甲苯二胺 --> 甲基二硝基苯
- Sigma Aldrich:584-84-9(sigmaaldrich)
- 用途二:主要用于聚氨酯产品，包括泡沫塑料、聚氨酯涂料、聚氨酯橡胶；聚酰亚胺纤维和胶粘剂等也有一些应用。
- MOL 文件:584-84-9.mol
- 下游产品:有机硅嵌段水性聚氨酯整理剂 --> 主链型液晶聚硅氧烷聚氨酯 --> SC系列聚氨酯涂饰剂
- 蒸气压:0.03 mm Hg ( 25 °C)
- F:10-21
- Acros Organics:甲苯基2,4-二异氰酸酯 Tolylene-2,4-diisocyanate,tech.,80%(584-84-9)
- 防护措施:剧毒。对皮肤、眼睛和粘膜有强烈的刺激作用。长期接触可引起支气管炎，少数病例呈哮喘状态、支气管扩张甚至肺心病等。大鼠在（0.5～1)ppm的浓度下，每天吸入6小时，吸入5～10天，即可致死。人体吸入0.0005mg/L后，即发生严重咳嗽、气促。空气中最高容许浓度0.14mg/m3。界区内应安装排风装置。操作人员要戴好防护用具。
- 图谱信息:甲苯-2,4-二异氰酸酯(584-84-9)核磁图( 13 CNMR) 甲苯-2,4-二异氰酸酯(584-84-9)红外图谱(IR1) 甲苯-2,4-二异氰酸酯(584-84-9)质谱(MS)
- Alfa Aesar:2,4-二异氰酸酯甲苯,80% Toluene-2,4-diisocyanate, tech. 80%, remainder 2,6-diisocyanate(584-84-9)
- 用途一:用于纤维、泡沫塑料及橡胶的合成，也用作粘合剂
- 刺激数据:皮肤- 兔子 500 毫克/ 24小时 中度; 眼- 兔子 100 毫克 重度
- 敏感性:Moisture Sensitive
京ICP备2020036287号