Ethyl dichlorophosphate 二氯磷酸乙酯

CAS 1498-51-7 MFCD00002069

化学结构图

1498-51-7
SMILES: CCOP(=O)(Cl)Cl

化学属性

Mol. FormulaC2H5Cl2O2P
Mol. Weight162.93
Density1.373
Refractive index1.4320 to 1.4360
Boiling Point60-65 °C at 10 mmHg
Flash Point>110°C
Appearance 本品为无色液体,b.p.58~64℃/1.73~2.0kPa,本品性质极为活泼,能与醇发生醇解反应,生成氯代烷和水。
Melting Point-42.5 °C

别名和识别编码

Chemical NameEthyl Dichlorophosphate
Synonym Ethyl phosphorodichloridate {LY} Ethyl phosphorodichloridate {} {LY} Ethyl phosphorodichloridate {} {} {LY} Ethyl phosphorodichloridate {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphorodichloridate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl phosphoro
MDL NumberMFCD00002069
CAS Number1498-51-7
EC Number216-099-0
Beilstein Registry Number1,332
PubChem Substance ID15158
Chemical Name Translation二氯磷酸乙酯
Reaxys-RN506857
Wiswesser Line NotationOPGGO2
LabNetwork Molecule IDLN00223163
InChIInChI=1S/C2H5Cl2O2P/c1-2-6-7(3,4)5/h2H2,1H3
Canonical SMILESO=P(Cl)(Cl)OCC
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分类

  • {uni_hamburg} no charge; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Phosphorus Compounds, Phosphorus Halides
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂

相关文献及参考

  • Short: III/20a Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cl Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20a Year: 1988 Keyword: NQR ISBN: 3-540-18161-X ISBN: 978-3-540-18161-3 Internet Resource: DOI:10.1007/b31153 RefComment: IX,677 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: III/38A Title: Refractive Indices of Inorganic, Organometallic, and Organononmetallic Liquids and Binary Liquid Mixtures Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/38A Year: 1996 Keyword: organicmetallic compounds; inorganic compounds; refractive index; liquids; mixtures ISBN: 3-540-60539-8 ISBN: 978-3-540-60539-3 Internet Resource: DOI:10.1007/b55612 RefComment: VII, 400 pages, Hardcover Abstract: Volume III/38 Optical Constants provides critically evaluated data on refractive indices of inorganic and organic liquids and their wavelength dependence (dispension). Part A contains the inorganic, organometallic, and organononmetallic liquids, and the binary liquid mixtures (about 900 pure substances and their mixtures). Part B contains data of more than 7600 organic liquids.
  • Short: IV/16 Title: Surface tension of pure liquids and binary mixtures Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: IV/16 Year: 1997 Keyword: organic compounds; surface tension; liquids; mixtures ISBN: 3-540-63276-X ISBN: 978-3-540-63276-4 Internet Reso

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R26 Very toxic by inhalation 吸入极毒
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P316
  • P301+P330+P331
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P316
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H330 Fatal if inhaled 吸入致命
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTD4390000
Hazard Codes T+,C C T+,C,Xi
UN Number 2927
Packing GroupII
Hazard Class6.1/8
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 564 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0530306

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2350 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - changes in structure or function of salivary glands
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0528775

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Gastrointestinal - ulceration or bleeding from stomach
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0528775

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 上游原料:乙醇 --> 乙醚 --> 石油醚 --> 三氯氧磷 --> 三乙胺 --> 挥发性漆稀释剂 --> 三酯
  • 二氯磷酸乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0488 二氯磷酸乙酯 Ethyl Phosphorodichloridate 25G 616元 2010/06/21 118381000 二氯磷酸乙酯 Ethyl dichlorophosphate 97% 100 GR 2459元 2010/06/21 118380250 二氯磷酸乙酯 Ethyl dichlorophosphate 97% 25 GR 810元
  • Sigma Aldrich:1498-51-7(sigmaaldrich)
  • TCI Shanghai:聚乙烯吡咯烷酮 K 30 黏均分子量40,000 Ethyl Phosphorodichloridate,>;98.0%(T)(1498-51-7)
  • 用途一:O-乙基磷酰二氯在农药上用于制备杀线虫剂灭线磷、苯线磷和杀菌剂敌瘟磷等。
  • 方法一:O-乙基磷酰二氯的制备采用三氯氧磷与无水乙醇直接反应。 在搅拌和冷却的条件下,将无水乙醇滴加到等摩尔的三氯氧磷中,控制滴加温度在40℃左右,滴完后继续反应4h,边搅拌边抽出盐酸气。所得产品收率约90%,含量在91%以上。 由于反应产物活性很强,常温下遇水或醇易发生水解或醇解反应,生成相应的副产物。反应产生的HCl若不及时排出,长时间与原料乙醇接触也会发生副反应。副C 2 H 5 OH+HCl→C 2 H 5 Cl+H 2 O 为了减少这些副反应的发生,在工艺上常采取以下措施:①所用原料和反应体系必须无水,且要求反应在低温(O℃以下)和微压的条件下进行;②三氯氧磷一般过量30%~150%,有时还加入一定量的二甲苯作稀释剂,既有利于热的扩散,也防止生成二酯、三酯等副产物;③反应后在真空条件下(一般在2.66kPa)脱溶,并回收过量的三氯氧磷。
  • 下游产品:灭克磷 --> 苯线磷 --> 克瘟散 --> 硫线磷
  • Acros Organics:二氯磷酸乙酯 Ethyl dichlorophosphate, 97%(1498-51-7)
  • MOL 文件:1498-51-7.mol
  • MSDS 信息:Ethyl phosphorodichloridate(1498-51-7).msds

系列性分类


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