Methyl Gallate 3,4,5-三羟基苯甲酸甲酯

CAS 99-24-1 MFCD00002194

化学结构图

99-24-1
SMILES: COC(=O)c1cc(O)c(O)c(O)c1

化学属性

Mol. FormulaC8H8O5
Mol. Weight184.15
Melting Point201-203 °C
TSCAYes
Solubilityethanol: 50 mg/mL, clear
Density1.501
Stability对湿度敏感
Boiling Point278.08 °C at 760 mmHg

别名和识别编码

Chemical NameMethyl Gallate
MDL NumberMFCD00002194
CAS Number99-24-1
Synonym Methyl gallate {LY} Methyl gallate {} {LY} Methyl gallate {} {} {LY} Methyl gallate {} {} {} {LY} Methyl gallate {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl gallate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID7428
EC Number202-741-7
Beilstein Registry Number2113180
Merck Number4345
Chemical Name Translation3,4,5-三羟基苯甲酸甲酯
Reaxys-RN2113180
Wiswesser Line NotationQVR CQ DQ EQ
LabNetwork Molecule IDLN00195806
InChIInChI=1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
Canonical SMILESO=C(OC)C1=CC(O)=C(O)C(O)=C1
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分类

  • {SNA} Alcohols, Monomers, Polymer Science, 材料科学
  • {SNA} Alcohols, Materials Science, Monomers, Polymer Science

产品应用

  • 抗氧剂。光刻胶剥离液成分，用于液晶显示器等，也可或高纯医药制剂中。

相关文献及参考

  • [2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50.
  • [3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705.
  • [4]. Wang CR, et al. First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa). Environ Toxicol Pharmacol. 2014 Mar;37(2):626-37.
  • Beilstein:10(3)2076
  • [1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50.
  • [1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50.
  • [2]. Hsieh TJ, et al. Protective effect of methyl gallate

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSLW8000000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Hazard Codes Xn Xn,Xi
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 784 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),286,1982

其他信息

  • MSDS 信息:Methyl gallate(99-24-1).msds
  • 图谱信息:没食子酸甲酯(99-24-1)核磁图( 1 HNMR) 没食子酸甲酯(99-24-1)核磁图( 13 CNMR) 没食子酸甲酯(99-24-1)红外图谱(IR1) 没食子酸甲酯(99-24-1)红外图谱(IR2) 没食子酸甲酯(99-24-1)质谱(MS)
  • 方法一:用没食子酸与甲醇在硫酸催化下酯化制得。
  • 上游原料:没食子酸
  • MOL 文件:99-24-1.mol
  • 溶于热水、乙醇、乙醚和甲醇。有刺激性。
  • 用途一:用作联苯双酚和其他药物的中间体
  • Sigma Aldrich:99-24-1(sigmaaldrich)
  • Alfa Aesar:3，4，5-三羟基苯甲酸甲酯,98% Methyl 3,4,5-trihydroxybenzoate, 98%(99-24-1)
  • TCI Shanghai:没食子酸甲酯 Methyl Gallate,>;98.0%(GC)(T)(99-24-1)
  • Acros Organics:3，4，5-三羟基苯甲酸甲酯酯/没食子酸甲酯 Methyl 3,4,5-trihydroxybenzoate, 99%(99-24-1)
  • 下游产品:4-溴-7-甲氧基-1,3-苯并二氧杂环戊烯-5-羧酸甲酯 --> 3,4-二羟基-5-甲氧基苯甲酸甲酯
  • 没食子酸甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30118326 没食子酸甲酯;棓酸甲酯;五棓子酸甲酯;3,4,5-三羟基苯甲酸甲酯 100g 58.5元 2011/04/16 G0017 没食子酸甲酯 Methyl Gallate 25G 302元 2011/04/16 G0017 没食子酸甲酯 Methyl Gallate 500G 2380元
  • 用途二:联苯双酯的中间体。也是橡胶防老剂。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. M - Alphabetic
  5. META - METH - M
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Alcohols - Monomers
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters
  6. C6 to C7
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Monomers
  4. Acrylic Monomers 丙烯酸单体
  5. Polyfunctional Acrylics
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Substrates
  5. Substrates by Enzyme
  6. Superoxide dismutase
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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