Resorcinol 间苯二酚

CAS 108-46-3 MFCD00002269

化学结构图

108-46-3
SMILES: OC1CCCC(O)C1

化学属性

Mol. FormulaC6H6O2
Mol. Weight110.11
Boiling Point-
Melting Point109-111°C
Density1.271
Flash Point-
SolubilitySoluble in water (1000 mg/ml), DMSO, methanol, alcohol (111 mg/ml), and chloroform (slightly).,
TSCAYes
Autoignition Point1126 °F
Vapor Density3.8 (vs air)
Vapor Pressure1 mmHg ( 21.1 °C)
Stability对空气和光敏感

别名和识别编码

Chemical NameResorcinol
CAS Number108-46-3
Synonym Resorcinol {LY} Resorcinol {} {LY} Resorcinol {} {} {LY} Resorcinol {} {} {} {LY} Resorcinol {} {} {} {} {LY} Resorcinol {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Resorcinol {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID5054
EC Number203-585-2
Beilstein Registry Number6(2)802
MDL Number-
Reaxys-RN906905
Merck Number8155
Chemical Name Translation间苯二酚
Wiswesser Line NotationQR CQ
LabNetwork Molecule IDLN00196308
InChIInChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
Canonical SMILESOC1=CC=CC(O)=C1
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分类

  • {SNA} Analytical Stan
  • {SNA} Allium, Analytical Standards, Analytical/Chromatography, Artemisia, Chromatography, Life Sciences Standards, Ononis, Phytopharma Standards, Standards by Plant Genus, Zingiber
  • {SNA} Allium, Analytical Standards,
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Analyt

产品应用

  • An aromatic alcohol used as a chemical intermediate

相关文献及参考

  • Merck:14,8155
  • Merck:14,8155 Beilstein:6(2)802
  • Short: II/2
  • Short: II/27B
  • Strakosch, E.A. et al.: Arch. Dermat. Syphil., 48, 393 (1943); Dyson, G.M.: Pharm. J., 120, 582 (1928); Sabalitschka, T. et al.: Pharmazeutiche Zeitung, 81, 335 (1936);

安全信息

GHS Symbol
WGK Germany2
Hazard Codes Xn;N Xn,N
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H370 Causes damage to organs 导致器官损伤
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSVG9625000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P308+P311
  • P337+P313
  • P333+P313
  • P301+P312+P330
  • P302+P350
  • P305+P351+P338+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P333+P313+P362+P364
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P310+P330
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
Signal word Danger
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R38 Irritating to skin 刺激皮肤
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number UN 2876 6.1/PG 3 2876
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store a
Packing GroupIII
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4800 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   19,413,1959

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 166,437,1932

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
   2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan)  V.1-   1988-
   Volume(issue)/page/year: 4,105,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration o

{

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/m3/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 213 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZGIMAL Z

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   63,47,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 80 mg/L
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,533,1982

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 135,109,1984

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 40 mg/L
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,533,1982

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1600 mg/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   14,251,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volu

Restrict 危险品

其他信息

  • 上游原料:氢氧化钠 --> 盐酸 --> 硫酸 --> 苯 --> 发烟硫酸 --> 正丁醇 --> 3-
  • F:3-8-9-23
  • FEMA:3589
  • 急性毒性:口服-大鼠LD50: 301 毫克/公斤;口服-小鼠LD50: 200 毫克/公斤
  • Acros Organics:间苯二酚 Resorcinol, 98%(108-46-3)
  • {Chemical
  • 常规方法:用木桶内衬塑料袋包装，每桶重30
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 间苯二酚 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 方法二:1.苯磺酸用发烟硫酸磺化、中和，再经碱熔、酸化、正丁醇萃取、蒸去溶剂后，经蒸馏而得成品。2.由间二硝基苯加氢制得间苯二胺，再由间苯二胺水解制得。3.间氨基苯酚水解制得。间苯二酚也
  • 所属类别一:农药中间体: 杀虫剂中间体: 有
  • 可燃性危险特性:可燃; 燃烧产生有毒氯化物刺激烟雾
  • Resorcinol is an aromatic alcohol useful in the synthesis of pharmaceuticals and various organic compounds as a chemical intermediate. Resorcinol may be produced in bacteria from other phenolic compounds, and may undergo further conversion to alicyclic products and eventual oxidation to acetyl-CoA. Resorcinol cytotoxicity and cytokine release in human epidermal keratinocytes has been studied. Resorcinol is also used in platicizers and diazo dyes. It can be used in the qualitative determination of ketoses in the Seliwanoff test.。
  • {Chemicalb
  • {
  • 下游产品:间亚苯基二苯甲酸酯 --> 荧光素 --> 异硫氰酸荧光素 --> 色甘酸钠 --> 乙胺香豆素盐酸盐 --> 2,4-二羟基苯甲酸 --> 8-乙酰基-7-羟基-4-甲基-2H-1-苯并吡喃-2-酮 --> 4-己基间苯二酚 --> 弱酸性红棕 V --> 5-氨基荧光素 --> 7-乙酰氧基-4-甲基香豆素 --> 丁苯吡胶乳 --> 酸性棕354 --> 3-氯-4-甲基-7-羟基香豆素 --> 3-乙氧基苯酚 --> 甲基伞形酮 --> 间羟基二苯胺 --> 1-[4-(苯甲酰氧基)-2-羟基苯基]-3-苯基-1,3-丙二酮 --> 酸性棕 75 --> 吲哚洛尔 --> 3-苄氧基苯酚 --> 1-[2,4-双(苯甲酰氧基)苯基]乙酮 --> 2',4'-二羟基苯己酮 --> 4-氧杂-4,5,
  • {C
  • MSDS 信息:间苯二酚(108-46-3).msds
  • 所属类别二:食品添加剂: 食用香料（增香剂）: 天然等同香料和人造香
  • 图谱信息:间苯二酚(108-46-3)红外图谱(IR1) 间苯二酚(108-46-3)红外图谱(IR2) 间苯二酚(108-46-3)质谱(MS) 间苯二酚(108-46-3)核磁图( 1 HNMR) 间苯二酚(108-46-3)核磁图( 13 CNMR)
  • 使用限量:FEMA(mg/kg)：焙烤制品15.0；肉制品、汤料、调味品、肉羹，5.0；小吃食
  • Resorcinol is an aromatic alcohol useful in the synthesis of pharmaceuticals and various organic compound

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. Q-Z - Alphabetical Listings
  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Stains & Dyes, A to Z - Stains and Dyes
  5. Q-R - Stains & Dyes, A to Z
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Protected Alcohols/Phenols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Polyols - Oxygen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  5. Q-S, Puriss p.a. - Puriss p.a.
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols
  1. Materials Science 材料科学
  2. Pressure & Heat Sensitive Recording Materials
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  5. Natural Dyes

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