Sodium salicylate 水杨酸钠

CAS 54-21-7 MFCD00002440

化学结构图

54-21-7
SMILES: [Na+].[O-]C(=O)C1C=CC=CC=1O

化学属性

Mol. FormulaC7H5NaO3
Mol. Weight160.10
Density1.015
Melting Point>300 °C
TSCAYes
SolubilitySoluble in water (1000 g/l) at 20 °C, ethanol, and glycerol.
Stability对光敏感

别名和识别编码

Chemical NameSodium salicylate
Synonym Sodium Salicylate {LY} Sodium Salicylate {} {LY} Sodium Salicylate {} {} {LY} Sodium Salicylate {} {} {} {LY} Sodium Salicylate {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium Salicylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number54-21-7
EC Number200-198-0
Beilstein Registry Number3732792
MDL NumberMFCD00002440
PubChem Substance ID24899533
Merck Number14,8332
Chemical Name Translation水杨酸钠
Wiswesser Line NotationQVR BQ &-NA-
LabNetwork Molecule IDLN03240012
Canonical SMILESO=C(O[Na])C1=CC=CC=C1O
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分类

  • {SNA} Carbohydrates, Core Bioreagents, Pharmacopoeia, Pharmacopoeia A-Z,
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards S - T, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Analytical Reagents for General Use, Essential Chemicals, Puriss p.a.,

产品应用

  • 有机合成原料;防腐剂;测胃液中游离酸的试剂;点滴分析二氧化铀。解热镇痛药和抗风湿药。

相关文献及参考

  • Short: II/3
  • Short: IV/1a
  • Short: IV/1b
  • Merck:14,8332 Beilstein: 10,IV,125
  • Merck:14,8332

安全信息

Signal word Warning
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36 Irritating to eyes 刺激眼睛
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSVO5075000
Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry an
Hazard Codes Xn
TYPE OF TEST            : LDL

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,572,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Behavioral - toxic psychosis
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - sweating
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   126,806,1944

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APSVAM Acta Paediatrica Scandinavica.  (Almqvist & Wiksell International,
   POB 4627, S-11691 Stockholm, Sweden)  V.54-80    1965-91    For publisher
   information, see APAEEL  Volume(issue)/page/year: 59,517,1970

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1392,1935

{hazard_co

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,1,1996

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 240 mg/L
REFERENCE :
   BIORAK Biochemistry (English Translation).  Translation of BIOHAO.  (Plenum
   Pub. Corp., 233 Spring St., New York, NY 10013)  V.21-    1956-
   Volume(issue)/page/year: 34,934,1969

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 30 mg/L
REFERENCE :
   BIORAK Biochemistry (English Translation).  Translation of BIOHAO.  (Plenum
   Pub. Corp., 233 Spring St., New York, NY 10013)  V.21-    1956-
   Volume(issue)/page/year: 34,934,1969

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 600 mg/kg
REFERENCE :
   BIOHAO Biokhimiya (Moscow).  For English translation, see BIORAK.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34,1151,1969

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,1,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 33,43A,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(12),32,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 220,385,1968

其他信息

  • 下游产品:水杨酸 --> 柳酸苄酯 --> 3,6-二氯-2-羟基苯甲酸 --> 媒介黄 1
  • Acros Organics:水杨酸钠 Salicylic acid, sodium salt, 99+%(54-21-7)
  • 易溶于水(1:0.8,25℃)和甘油(1:5),能溶于95%乙醇(1:11),几乎不溶于醚、氯仿和苯。水溶液呈微酸性(pH5-6)。久露光线中变粉红色。无臭或微带特殊的臭气,味甜呀不适。
  • 图谱信息:水杨酸钠(54-21-7)红外图谱(IR1) 水杨酸钠(54-21-7)红外图谱(IR2) 水杨酸钠(54-21-7)Raman光谱
  • F:8
  • 用途三:有机合成原料、防腐剂、测胃液中游离酸的试剂。解热镇痛药和抗风湿药。
  • Alfa Aesar:水杨酸钠,99% Sodium salicylate, 99%(54-21-7)
  • MOL 文件:54-21-7.mol
  • 用途一:解热镇痛、抗风湿药,用于活动性风湿病、类风湿关节炎等疾病的治疗
  • MSDS 信息:水杨酸钠(54-21-7).msds
  • 上游原料:连二亚硫酸钠 --> 水杨酸 --> 乙二胺四乙酸
  • 水杨酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30169317 水杨酸钠 250g 27元 2011/08/23 30169327 水杨酸钠 250g 26元 2011/08/23 HW6610901 水杨酸钠 250g 475元
  • 海关编码:29182100
  • 用途二:用于微量分析测定二氧化铀及有机合成,还用作防腐剂等
  • 方法一:将水杨酸和碳酸氢钠交叉加入蒸馏水中,温度保持60℃,并保持呈酸性状态,同时加入适量乙二胺四乙酸(EDTA)及保险粉。升温至85℃,反应半小时。将合格的反应液经过滤送入沸腾床,85℃干燥得水杨酸。
  • Sigma Aldrich:54-21-7(sigmaaldrich)
  • 用途四:有机合成原料;防腐剂;测胃液中游离酸的试剂;点滴分析二氧化铀。解热镇痛药和抗风湿药。
  • 外观性质:白色鳞片或粉末,无气味,久露光线中变粉红色。
  • 敏感性:Light Sensitive

系列性分类